Metyrapone

An oral 11‐beta hydroxylase inhibitor administered during the evening reduced systolic and diastolic blood pressure for adults with mild autonomous cortisol secretion, researchers reported in Clinical Endocrinology.

The FDA on Friday approved a new biologic as add-on maintenance treatment for inadequately controlled chronic rhinosinusitis with nasal polyps, according to Amgen and AstraZeneca.

SAN DIEGO — Patients with chronic rhinosinusitis with nasal polyps saw improvements across all endpoints with tezepelumab, according to an abstract presented here.

To achieve optimal outcomes in Cushing’s syndrome, both clinicians and patients need to be prepared for the type and duration of symptoms that patients may experience during treatment and recovery.

The Endocrine Society recommends medical management with a moderate level of evidence; in particular, steroidogenesis inhibitors as a second-line treatment after surgery for people with Cushing’s disease, either with or without radiotherapy, and as primary treatment for ectopic adrenocorticotropic hormone (ACTH) secretion. The guideline also recommends pituitary-directed medical treatments for patients who are not surgical candidates or who have persistent disease after surgery. The choice of medical therapy should be guided by efficacy, individual patient factors and cost.

More than a century has passed since neurosurgeon and pathologist Harvey Cushing described the disease that would eventually bear his name, but only recently have several key discoveries offered patients with the condition real hope for a cure.

Hypercortisolemia in Cushing’s syndrome can be controlled with Metopirone therapy, according to recent study findings published in The Journal of Clinical Endocrinology & Metabolism.