Published results showed certain preoperative and postoperative doses of osocimab used in patients undergoing unilateral knee arthroplasty met noninferiority and superiority criteria for the incidence of venous thromboembolism compared with enoxaparin.

Researchers randomly assigned 813 patients undergoing unilateral knee arthroplasty to receive single IV osocimab postoperative doses of 0.3 mg/kg (n=107), 0.6 mg/kg (n=65), 1.2 mg/kg (n=108) or 1.8 mg/kg (n=106); preoperative doses of 0.3 mg/kg (n=109) or 1.8 mg/kg (n=108); or 40 mg of subcutaneous enoxaparin once daily (n=105) or 2.5 mg of oral apixaban twice daily (n=105) for at least 10 days or until venography. Researchers considered venous thromboembolism incidence between 10 and 13 days postoperatively as the primary outcome and major or clinically relevant non-major bleeding assessed until 10 to 13 days postoperatively as the primary safety outcome.