PHILADELPHIA — The risk for migraine attack may increase with the presence of each premonitory symptom, including excessive yawning, mood changes and excessive fatigue, according to early results from a study presented at the American Headache Society Annual Meeting.

“Premonitory symptoms are defined as nonpainful symptoms that occur hours to days before, and can be harbingers of, a migraine attack,” Peter Schmidt, MD, MSc, of Zosano Pharma, and colleagues wrote in the abstract. “They are increasingly recognized as part of the continuum of migraine as a brain disease.”