Treatment with olanzapine plus samidorphan, an opioid antagonist, resulted in 37% lower weight gain than treatment with olanzapine plus placebo in patients with schizophrenia, according to data from a phase 2 study.

In previous preclinical and phase 1 clinical studies, samidorphan has been shown to mitigate weight gain associated with olanzapine use, William F. Martin, PhD, of Alkermes, Inc., and colleagues wrote in American Journal of Psychiatry.