In a phase 3 study, cariprazine, both taken at 1.5 mg per day and 3 mg per day, was more effective than placebo in improving depressive symptoms in adults with bipolar I depression.

Prior research has shown cariprazine’s efficacy over placebo in reducing depressive symptoms in this patient population, but the difference remained significant for only the 1.5 mg per day dosage after adjustment, Willie Earley, MD, of Allergen Inc., and colleagues wrote.