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Study shows genetic risk gradient across schizophrenia, bipolar disorder

November 22, 2017

Recent findings indicated a polygenic risk gradient across schizophrenia and bipolar disorder, which was associated with the presence and severity of mood-incongruent psychotic symptoms.

“Mood-incongruent psychotic features are associated with poor prognosis and poor lithium response and are qualitatively similar to the prototypic symptoms of [schizophrenia], suggesting that [bipolar disorder] with psychosis and particularly mood-incongruent psychotic features may specify a subgroup or stratum with stronger etiological links to [schizophrenia],” Judith Allardyce, MRCPsych, PhD, of Cardiff University, Wales, and colleagues wrote. “Stratified linkage and candidate-gene studies of [bipolar disorder] associations with chromosomal regions and genes implicated in [schizophrenia]show stronger effects in psychosis and mood-incongruent subsamples, providing some support for this causal heterogeneity hypothesis; however, lack of consistency in earlier linkage and candidate-gene studies renders the overall support weak.”

FDA News

FDA grants fast track designation to lumateperone for schizophrenia

November 22, 2017
Intra-Cellular Therapies Inc. recently announced the FDA granted fast track designation for lumateperone for treatment of schizophrenia. Lumateperone is a dopamine…

Teen alcohol, drug dependence linked to poor life outcomes in adulthood

November 21, 2017
Teenagers who are dependent on alcohol and marijuana are significantly less likely to attain life goals such as academic success and the achievement of full-time…
In the Journals

Physical activity linked to mood, anxiety levels

November 21, 2017
Most individuals seeking outpatient mental health care reported their mood and anxiety levels were linked to physical activity. “Physical activity has been shown…
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CNE Article

Effect of Psychiatric Symptoms on Employment Outcomes for Individuals Receiving Supported Employment Services: A Preliminary Study

Journal of Psychosocial Nursing and Mental Health Services
Online Advanced Release, November 8, 2017
Psychiatric symptoms are often cited by community-based providers as barriers to employment for individuals with mental…
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Integrated Psychiatry: July 2017

AKH Inc., Advancing Knowledge in Healthcare and Psychiatric Annals

People with serious psychiatric disorders suffer 2-fold: first from their psychiatric burdens and then from medical…
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Psych Congress

Psych Congress

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VIDEO: How can we protect our brains?

September 18, 2017
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