Study findings indicated that adjunctive antidepressants were linked to a lower risk for psychiatric hospitalization and ED visits compared with alternative psychotropic medication strategies in patients with schizophrenia already taking an antipsychotic.

“The effectiveness of combinations of antipsychotic medications remains unclear; reviews of this treatment strategy agree on the need for further investigation,” T. Scott Stroup, MD, MPH, from the department of psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, and colleagues wrote in JAMA Psychiatry.