Study findings revealed that specific connectivity profiles — which comprised fronto-thalamic streamlines in the brain — can predict clinical outcome of deep brain stimulation for obsessive-compulsive disorder.

“Although it seems certain that [deep brain stimulation] has effects on distributed brain networks, it remains highly unclear which networks are associated with clinical improvement,” Juan Carlos Baldermann, MD, from the department of psychiatry and psychotherapy, University of Cologne, Germany, and colleagues wrote in Biological Psychiatry.