Preliminary study results reported the beneficial effect of treatment with Trintellix on subjective sleep and daytime sleepiness in patients with insomnia and major depressive disorder.

“Treating insomnia comorbid with depression may be challenging considering that many antidepressant medications can adversely affect sleep quality and continuity,” Claudio Liguori, MD, from the University of Rome Tor Vergata, and colleagues wrote in the British Journal of Clinical Pharmacology. “Although the efficacy and safety of [vortioxetine] treatment have been already demonstrated on depressive symptoms in trials comparing this drug vs. placebo, no studies investigated the effect of [vortioxetine] on sleep in depressed patients.”