CVD risk increased in monogenic familial hypercholesterolemia

MIAMI — Patients with monogenic familial hypercholesterolemia had a higher risk for CVD compared with those without the familial hypercholesterolemia-causing variant or patients with polygenic familial hypercholesterolemia, according to the third-place oral poster winner presentation at the National Lipid Association Scientific Sessions.

Liam Brunham, MD, PhD, assistant professor in the department of medicine at the University of British Columbia in Vancouver, Canada, and colleagues analyzed data from 626 patients (mean age, 46 years; 51% women) with possible (n = 170), probable (n = 227) or definite familial hypercholesterolemia (FH; n = 229) based on Dutch Lipid Clinic Network criteria. Targeted sequencing was performed for genes that have been shown to cause FH and common variants that influence LDL. Researchers also calculated polygenic risk scores.