Patients undergoing multiple valve replacement with prolonged cardiopulmonary bypass who were given nitric oxide had a decreased risk for acute kidney injury, worsening of chronic kidney disease and major adverse kidney events, according to a study published in the American Journal of Respiratory and Critical Care Medicine.
“Previous studies showed that prolonged cardiopulmonary bypass causes disruption of circulating red blood cells and the release of hemoglobin, which can cause acute kidney injury, leading to kidney failure and the need for long-term hemodialysis,” Lorenzo Berra, MD, medical director of respiratory care at Massachusetts General Hospital and assistant professor at Harvard Medical School, said in a press release. “We tested whether administration of nitric oxide, a gas normally produced by cells in the lining of blood vessels, might render hemoglobin ‘inert,’ thereby decreasing the risk of both acute and chronic kidney injury.”
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