Hematology/Oncology

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Atezolizumab-based triplet effective, but toxic, for follicular lymphoma

Atezolizumab-based triplet effective, but toxic, for follicular lymphoma
December 11, 2017

Read the Perspective from Ann S. LaCasce, MD

ATLANTA — A combination of atezolizumab, obinutuzumab and bendamustine demonstrated first-line activity among previously untreated patients with follicular lymphoma, but also resulted in widespread adverse events and one treatment-related death, according to an interim analysis presented at the ASH Annual Meeting and Exposition.

“The aims of this study were to evaluate the safety and preliminary efficacy of the novel combination of atezolizumab [Tecentriq, Genentech] plus obinutuzumab [Gazyva, Genentech] plus bendamustine in patients with newly diagnosed follicular lymphoma,” Anas Younes, MD, chief of lymphoma service at Memorial Sloan Kettering Cancer Center, said during his presentation. “We also had a safety arm to confirm the safety of combining the three therapies for frontline treatment.”

Meeting NewsPerspective

Brentuximab vedotin combination superior to standard chemotherapy in Hodgkin lymphoma

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ATLANTA — Brentuximab vedotin in combination with doxorubicin, vinblastine and dacarbazine induced superior modified PFS compared with standard chemotherapy…
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Fatty liver index useful for predicting precancerous colon polyps

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Patients with a high fatty liver index, a noninvasive method used to predict non-alcoholic fatty liver disease, showed a higher risk for colorectal adenomas, according…
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BLU-285 induces rapid responses in advanced systemic mastocytosis

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ATLANTA — BLU-285 appeared active and safe among patients with advanced systemic mastocytosis, according to phase 1 data presented during the plenary session of…
Meeting NewsPerspective

Graft failure remains concern following umbilical cord blood transplantation for leukemia

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ATLANTA —Twelve percent of adults with acute myeloid or acute lymphoblastic leukemia who received umbilical cord blood transplantation experienced graft failure…
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