SAN ANTONIO — Extended adjuvant endocrine therapy with letrozole improved DFS compared with placebo among postmenopausal women with hormone receptor-positive breast cancer who completed previous adjuvant therapy with an aromatase inhibitor, according to 10-year results from the randomized NRG Oncology/NSABP B-42 trial presented at San Antonio Breast Cancer Symposium.

Extended letrozole also provided statistically significant improvements in breast cancer-free interval and distant recurrence. However, researchers reported no significant difference in OS with letrozole.