For pediatric patients with Crohn’s disease, proactive monitoring of Humira trough concentrations and dose adjustments improved rates of corticosteroid-free clinical remission.

Amit Assa , MD, MHA, of Schneider Children’s Medical Center of Israel, and colleagues wrote that therapeutic drug monitoring (TDM) is a common method to address loss of response during anti-TNF therapy, and treatment can be guided by either reactive or proactive strategies.