Gastroenterology

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IBS-D shows unique immune cell exhaustion vs. other subtypes

June 26, 2017

Patients with diarrhea-predominant irritable bowel syndrome appear to share a similar “exhaustion” in their T-cells during a symptom flare, differentiating them from other IBS subtypes, according to a letter published in Gut.

“For the first time, we’ve discovered that in patients with irritable bowel syndrome associated with diarrhea, their T-cells seem to be ‘out of puff’ or run down,” Patrick A. Hughes, PhD, of Adelaide Medical School and the South Australian Health and Medical Research Institute, said in a press release. “These normally active immune cells are less responsive to stimulation, secreting fewer mediators and dividing less. This type of response is often observed in chronic infections.”

In the Journals

Preop chemo-related liver injuries persist for 9 months or longer

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In patients treated with preoperative chemotherapy prior to resection for colorectal liver metastases, sinusoidal dilation and nodular regenerative hyperplasia did not…

AbbVie receives CHMP positive opinion for Maviret for chronic HCV

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AbbVie has received a positive opinion from the Committee for Medicinal Products for Human Use for its ribavirin-free regimen Maviret for the treatment of chronic…

8 highlights in GI: Alzheimer’s, exercise, obesity and autism

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June has proven to be a month of hot topics in gastroenterology news, with significant advances in therapeutics, disease prevention and the microbiome. The latest…

EMA recommends approval of Humira biosimilar Imraldi

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The European Medicines Agency has recommended the approval of the Imraldi, making it the third anti-TNF biosimilar candidate to receive a positive opinion from the…
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This activity is supported by an educational grant from Receptos.

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