Results from a dual-center retrospective study demonstrated patients with adolescent idiopathic scoliosis who had curve progression and those without curve progression were not significantly different with regard to ScoliScores — a DNA-based prognostic test.
Researchers administered the ScoliScore test to 126 patients with a mean age of 12.2 years with adolescent idiopathic scoliosis and followed them until they researched skeletal maturity. The mean follow-up period was 28.5 months. Investigators also collected demographic, clinical and radiographic data for each patient before they completed the test. Patients were categorized into one of the following groups: patients with a curve progression of greater than 40° (the progression group); and patients without a curve progression greater than 40° (non-progression group).
Results showed the mean ScoliScore for all patients was 103 points. The 27 patients in the curve progression group had a mean score of 107 points, and the non-progression group had a mean score of 102 points.
Investigators noted there was no correlation between curve progression unadjusted and ScoliScore value with regard to the prescription of a brace. The ScoliScore test had a positive predictive value of 0.27, with a negative value of 0.87. The curve progression was not significantly different between patients with low-risk ScoliScores (12.9%), and high-risk ScoliScores (26.7%). Brace-wear did not significantly affect progression rates, according to researchers. ‒ by Monica Jaramillo
Disclosures: Roye reports he receives research support from the Scoliosis Research Society, OMeGA and the Pediatric Orthopaedic Society of North America. Please see the full study for a list of all other authors’ relevant financial disclosures.