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Elevated adipsin linked with pulmonary arterial hypertension in patients with systemic sclerosis

June 30, 2017

Among patients with systemic sclerosis, elevated levels of adipsin were linked with pulmonary arterial hypertension, according to a recently published analysis.

“Taken together, these findings suggest a previously unrecognized pathogenic role for adipsin in [systemic sclerosis] SSc and SSc [pulmonary arterial hypertension] PAH, and highlight adipsin as a novel marker of vascular manifestations with important prognostic and potentially therapeutic value,” Benjamin D. Korman, MD, from Northwestern University, and colleagues wrote. “Moreover, in light of the essential role of adipsin in modulating complement pathway activity, our results implicate the complement system in SSc-associated PAH.”

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This activity is supported by an educational grant from Genentech, Inc.

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The Patient with Back Pain

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Back pain is a common disorder, with nearly 80% of adults experiencing lower back pain over the course of their…
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