Results from this registry study indicated a correlation between the anticarbamylated protein antibodies and greater disability and disease activity in adult patients with early inflammatory arthritis.
Researchers identified 1,995 patients with inflammatory polyarthritis from the Norfolk Arthritis Register. Investigators obtained the health assessment questionnaire (HAQ) scores, DAS28 scores, and measured C reactive protein, rheumatoid factor (RF), anticitrullinated protein antibodies (ACPA) and anticarbamylated protein (anti-CarP) antibodies at the baseline. During a 20-year period, investigators collected HAQ scores and DAS28 scores. With generalized estimating equations, investigators determined the correlation between status of the anti-CarP antibodies, and longitudinal HAQ and DAS28 scores.
Findings showed a significant association between the anti-CarP antibodies and greater disability, higher disease activity and the HAQ multivariate beta-coefficient, which remained significant within the ACPA-negative subgroups. Investigators noted the correlation among RF, ACPA and anti-CarP antibodies was additive with regard to the random effects model. ‒ by Monica Jaramillo
Disclosure: The study was funded by AstraZeneca/Medimmune.