Women who regularly consumed large amounts of alcohol had a significantly higher risk of developing psoriatic arthritis than moderate drinkers or those who were abstinent, according to data from the Nurses’ Health Study.
Researchers studied data from 1,137,763 person-years of follow-up of patients from the registry between 1991 and 2005. Information about alcohol use was collected in 1991, 1995, 1999 and 2003, and in 2005, participants were asked if they had been diagnosed with psoriatic arthritis (PsA). Intake was classified as none, 0.1 g to 14.9 g/day (moderate intake), 15 g to 29.9 g/day (high intake), and equal to or more than 30 g/day (excessive intake).
A total of 141 patients with PsA were identified and validated through the Psoriasis Screening Tool (PST) and the Psoriatic Arthritis Screening and Evaluation (PASE). Patients with PsA at baseline were excluded.
Multivariate analyses showed women who consumed excessive amounts of alcohol had a hazard ratio (HR) of 4.45 compared with a HR of 0.70 in women who consumed moderate amounts of alcohol and a HR of 1.43 in women who consumed high amounts of alcohol.
The fully adjusted HR for women who consumed no alcohol was 1.43, but in women who drank moderate amounts of alcohol, the HR was 0.69, according to the researchers. In women with high intake of alcohol, the HR was 2.04, and a HR of 6.35 was seen in women who consumed excessive amounts of alcohol.
A significant association (HR 2.84) was seen with regular consumption of beer and the risk of developing psoriatic arthritis, according to the researchers. - by Shirley Pulawski
Disclosure: The researchers report no relevant financial disclosures.