Please refer to the full Prescribing Information at CIMZIAhcp.com.
Despite advances in our understanding of patients with nr-axSpA, the time to diagnosis can be lengthy. The median delay from symptom onset to diagnosis for a patient with axSpA can be between 5 and 8 years compared with a 9-month lag for patients with rheumatoid arthritis (Figure 6).1-4 Since women are more likely to experience a diagnostic delay and women represent a larger portion of patients with nr-axSpA, the diagnostic delay may be even greater in patients with nr-axSpA.2,3
In addition to a rheumatologist, patients with nr-axSpA may consult with a variety of healthcare providers, including specialists in radiology, pain medicine, physical medicine and rehabilitation, anesthesiology, or neurological or orthopedic surgery.5 The presence of extra-spinal manifestations, such as uveitis, enthesitis and psoriasis, can trigger an ophthalmologist, dermatologist or gastroenterologist to refer that patient to a rheumatologist and may result in earlier diagnosis.
Throughout a patient’s journey, he or she may receive a variety of misdiagnoses prior to being diagnosed with nr-axSpA. International Classification of Diseases, Tenth Revision (ICD-10) diagnostic codes that may be identified prior to the diagnosis of nr-axSpA include various inflammatory spondylopathies and back pain.5
Figure 6. The Time to Diagnosis of axSpA Is Longer Than That of RA1-4
axSpA, axial spondyloarthritis; RA, rheumatoid arthritis.
1. Chan KW, Felson DT, Yood RA, et al. The lag time between onset of symptoms and diagnosis of rheumatoid arthritis. Arthritis Rheum. 1994;37(6):814-820.
2. Seo MR, Baek HL, Yoon HH, et al. Delayed diagnosis is linked to worse outcomes and unfavourable treatment responses in patients with axial spondyloarthritis. Clin Rheumatol. 2015;34(8):1397-1405.
3. Masson Behar V, Dougados M, Etcheto A, et al. Diagnostic delay in axial spondyloarthritis: a cross-sectional study of 432 patients. Joint Bone Spine. 2017;84(4):467-471.
4. Sykes MP, Doll H, Sengupta R, Gaffney K. Delay to diagnosis in axial spondyloarthritis: are we improving in the UK? Rheumatology (Oxford). 2015;54(12):2283-2284.
5. UCB, Inc. Data on file.
©2019 UCB, Inc., Smyrna, GA 30080. All rights reserved.
Version: August 2019
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