Please refer to the full Prescribing Information at CIMZIAhcp.com.
The term spondyloarthritis (SpA) encompasses a spectrum of related inflammatory conditions with a predominance of either axial or peripheral manifestations.1 The figure illustrates the individual diseases within the SpA family spectrum (Figure 1).2
Patients with axial SpA (axSpA) have inflammation in the sacroiliac joints (SIJs) and/or the spine.2
Non-radiographic axSpA (nr-axSpA) comprises a subset of patients with axSpA who have no definitive structural damage to the SIJ evident on x-ray (Figure 2).2
Figure 1. nr-axSpA Comprises a Subset Of Patients Within the SpA Spectrum2,*
axSpA, axial spondyloarthritis; IBD, inflammatory bowel disease; SpA, spondyloarthritis.
*Diseases shown represent the predominant pattern of disease and do not illustrate the overlap of disease in the spectrum. Figure is not intended to suggest that a patient’s diagnosis is static.
Figure 2. Non-radiographic Axial Spondyloarthritis Is an Inflammatory Condition That Affects the Sacroiliac Joint (SIJ) Without Definite Structural Damage on X-ray2,3*
*SIJ includes the spine and sacroiliac joints, which connect the spine and hips. Inflammation typically starts in the SIJs (sacroiliitis) and progresses to the spine (spondylitis) over time.
1. Garg N, van den Bosch F, Deodhar A. The concept of spondyloarthritis: where are we now? Best Pract Res Clin Rheumatol. 2014;28(5):663-672.
2. Raychaudhuri SP, Deodhar A. The classification and diagnostic criteria of ankylosing spondylitis. J Autoimmun. 2014;48-49:128-133.
3. Deodhar A, Reveille JD, van den Bosch F, et al. The concept of axial spondyloarthritis: joint statement of the spondyloarthritis research and treatment network and the Assessment of SpondyloArthritis international Society in response to the US Food and Drug Administration's comments and concerns. Arthritis Rheumatol. 2014;66(10):2649-2656.
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Version: August 2019
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