Asthma

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Dupilumab shows promise for uncontrolled persistent asthma in phase 3 trial

September 12, 2017

Results from the phase 3 Liberty Asthma Quest trial demonstrated that the investigational drug, dupilumab, reduced severe exacerbations and improved lung function in patients with uncontrolled persistent asthma, according to a press release issued by Regeneron Pharmaceuticals and Sanofi.

“Approximately one million U.S. adults and adolescents live with uncontrolled, persistent asthma, and continue to experience serious asthma attacks, despite taking an intensive regimen of standard therapies,” George D. Yancopoulos, MD, PhD, president and chief scientific officer of Regeneron, said in the release. “Dupilumab has now demonstrated positive late-stage results in two serious allergic diseases — asthma and atopic dermatitis — with robust efficacy and an extensive safety database. These results continue to support our hypothesis that the [interleukin (IL)]-4/IL-13 pathway is a critical driver of allergic disease, and we remain committed to further investigating the IL-4/IL-13 pathway in other allergic diseases.”

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Tezepelumab lowers asthma exacerbations vs. placebo

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When compared with placebo, tezepelumab lowered clinically significant asthma exacerbations in adults with long-acting beta-agonists and medium-to-high doses of inhaled…
In the Journals

COPD, asthma cited as important contributors to disease burden worldwide

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In 2015, chronic obstructive pulmonary disease contributed to 3.2 million deaths worldwide and asthma contributed to 0.4 million deaths. These statistics demonstrate…
Feature

Pediatric asthma over 3 decades: The plateau beyond the epidemic

Infectious Diseases in Children, August 2017
From 1980 to 1987, the death rate from asthma in the United States rose from 1.3 per 100,000 population to 1.7, according to the CDC. Although asthma mortality rates had…
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CME Article

Diffuse Lung Disease in Children

Pediatric Annals, December 2010, Volume 39 Issue 12
A 3-month-old is brought in by her mother for evaluation because she said she believes the baby breathes faster than…
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Video
Meeting News Coverage

VIDEO: Reducing asthma medications safe, effective in certain patients

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