July 20, 2017
Autism was more common in children exposed to antidepressants during pregnancy, compared with children not exposed to antidepressants whose mothers had a history of psychiatric disorder.
“The fetal safety of antidepressant exposure during pregnancy has generated much debate after recent concerns of a possible association with autism in exposed offspring,” Dheeraj Rai, MBBS, MRC PSYCH, PhD, of University of Bristol, United Kingdom, and colleagues wrote. “In the past 5 years, several epidemiological studies have assessed the relation between antidepressant use during pregnancy and autism in offspring, but robust conclusions have been elusive. Although most studies found evidence of unadjusted associations, conclusions differed because of concerns about ‘confounding by indication.’”