Research published in JAMA Psychiatry showed that children aged 6 to 12 years presenting with high irritability and depressive/anxious mood were twice as likely to have suicidal thoughts or attempt suicide in adolescence than children with low irritability and depressive/anxious mood.
“Childhood assessment of irritability is important from a developmental perspective because childhood is the most relevant period in the manifestation of irritability,” Marie-Claude Geoffroy, PhD, McGill Group for Suicide Studies, Douglas Mental Health University Institute, department of psychiatry, McGill University, and colleagues wrote. “Despite the importance of childhood irritability in the characterization of mood disorders and depression, only two longitudinal population-based studies have investigated its predictive association with suicidality. Evidence exists on the independent effect of depression and irritability but is lacking on their joint effect on suicidal risk.”
To examine the joint relationship of childhood irritability and depressive/anxious mood profiles during childhood with later suicidality in adolescence, researchers performed a population-based cohort study using data from 1,430 children followed up for 17 years. Youth underwent assessment yearly during childhood and bi-yearly during adolescence. The investigators assessed irritability and depressive/anxious mood after teachers rated children at ages 6, 7, 8, 10 and 12 years using the Behaviors Questionnaire. They also assessed self-reported past-year suicidality at ages 13, 15 and 17 years.
Among the participants, 831 had combined no irritability and low depressive/anxious mood with low irritability and low depressive/anxious mood, 353 had moderate irritability and low depressive/anxious mood, 94 had high depressive/anxious mood only and 152 had both high irritability and depressive/anxious mood.
Analysis showed that youth with high irritability and high depressive/anxious mood during childhood were two times more likely to have suicidal thoughts or attempt suicide in their teen years than those showing depressive/anxious mood only or low irritability and low depressive/anxious mood (OR = 2.22; 95% CI, 1.32-3.74). Overall, 16.4% of children with high irritability and depressive/anxious symptoms reported rates of suicidality compared with 11% of those with the lowest symptom levels. Notably, girls presenting with high irritability and high depressive/anxious mood had higher risk for suicidality (OR = 3.07; 95% CI, 1.54-6.12) than boys.
Children with moderate irritability and low depressive/anxious mood were also more likely to attempt suicide or have suicidal thoughts, but to a lesser extent (OR = 1.51; 95% CI, 1.02-2.25). High depressive/anxious mood only was not linked to subsequent suicidality, but high irritability and depressive/anxious mood was linked with a higher suicide risk when compared with depressive/anxious mood only (OR = 2.28; 95% CI, 1.02-5.15).
“The value of assessing irritability as part of the suicide risk assessment should be investigated in future population-based and clinical studies. Because our findings are exploratory, additional studies are needed to test the putatively causal role of irritability on suicidality,” the authors wrote. “For instance, randomized intervention aiming at reducing childhood irritability, especially when accompanied by high depressive/anxious mood, should examine the effect of childhood irritability on future suicidal symptoms.” – by Savannah Demko
Disclosures: Geoffroy reports being a research fellow of the Fonds de Recherche du Quebec. Please see the full study for all other authors’ relevant financial disclosures.