Journal of Psychosocial Nursing and Mental Health Services

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Antihypertensives Used for Treatment of Psychiatric Disorders

Abstract

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

Generic (Brand) NameIndicationMechanisms of ActionFDA Approved Age RangeStrength of EvidenceTreatment Guidelines

FDA APPROVED

Clonidine ER (Kapvay®)ADHDCentral alpha2-adrenergic agonist6 to 17SufficientWolraich, M. L., Hagan, J. F., Allan, C., Chan, E., Davison, D., Earls, M., Evans, S. W., Flinn, S. K., Froehlich, T., Frost, J., Holbrook, J. R., Lehmann, C. U., Lessin, H. R., Okechukwu, K., Pierce, K. L., Winner, J. D., & Zurhellen, W., & Subcommittee on Children and Adolescents with Attention-Deficit/Hyperactive Disorder. (2019). Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 144(4), e20192528. https://doi.org/10.1542/peds.2019-2528

Guanfacine ER (Intuniv®)ADHDCentral alpha2-adrenergic agonist6 to 17Sufficient

OFF-LABEL USE

Prazosin (Minipress®)PTSD and trauma-related hyperarousal and nightmaresAlpha-adrenergic receptor blockadeN/AInsufficientU.S. Department of Veterans Affairs, Department of Defense. (2017). VA/DoD clinical practice guideline for the management of posttraumatic stress disorder and acute stress disorder. https://www.healthquality.va.gov/guidelines/MH/ptsd/VADoDPTSDCPGFinal012418.pdf

Propranolol (Inderal®)Autonomic hyperactivity related to anxietyBeta blockade reduces the physical signs of anxiety (tremor, shaky voice)N/AInsufficientExamples of off-label use: Sagar-Ouriaghli, I., Lievesley, K., & Santosh, P. J. (2018). Propranolol for treating emotional, behavioural, autonomic dysregulation in children and adolescents with autism spectrum disorders. Journal of Psychopharmacology (Oxford, England), 32(6), 641–653. https://doi.org/10.1177/0269881118756245
Wolf, M. A. (2020). A frequently missed diagnosis. The American Journal of Medicine, 133(8), 885. https://doi.org/10.1016/j.amjmed.2020.01.017
Authors

10.3928/02793695-20210104-79

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