Journal of Psychosocial Nursing and Mental Health Services

Clip & Save Drug Chart 

Drugs to Treat Bipolar Disorders

Abstract

Table

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Generic (Brand) NameBipolar DepressionManiaBipolar Maintenance

Aripiprazole (Abilify®)Off-label use for adults and pediatric patientsFDA approved for acute manic and mixed episodes in adults and pediatric patients ages 10 to 17 (as monotherapy and adjunct to lithium or valproate)FDA approved for bipolar I disorder in adults and pediatric patients ages 10 to 17 (as monotherapy and adjunct to lithium or valproate)
(Abilify Maintena®)FDA approved

Asenapine (Saphris®)FDA approved for acute manic and mixed episodes in adults and pediatric patients ages 10 to 17 (as monotherapy and adjunct to lithium or valproate)Off-label use

Carbamazepine (Carbatrol®, Equetro®, Tegretol®, Tegretol® -XR)Off-label useEquetro is FDA approved for acute manic and mixed episodesOff-label use

Cariprazine (Vraylar®)FDA approvedOff-label use

Chlorpromazine (Thorazine®)FDA approvedOff-label use

Clonazepam (Klonopin®)Off-label use

Clozapine (Clozaril®)Off-label use

Divalproex sodium delayed release (Depakote®), divalproex sodium extended release (Depakote® ER)Off-label useFDA approved for acute maniaOff-label use
Valproate sodium injectable (Depacon®)FDA approved for acute mania
Valproic acid (Depakene®), valproic acid delayed release (Stavzor®)Off-label useFDA approved for acute maniaOff-label use

Eslicarbazepine acetate (Aptiom®)Off-label use

Gabapentin (Neurontin®)Off-label use

Haloperidol (Haldol®)Off-label useOff-label use
(Haldol® Decanoate)Off-label use

Lamotrigine (Lamictal®, Labileno®, Lamictin®)Off-label useOff-label use as an adjunctive and second-line therapyFDA approved for bipolar I disorder and adjunctive therapy to valproate

Lithium (Eskalith®, Eskalith CR®, and others)Off-label useFDA approvedFDA approved

Lorazepam (Ativan®)Off-label use

Loxapine (Adasuve®)FDA approved for psychomotor agitation in bipolar I disorder

Lurasidone (Latuda®)FDA approvedOff-label useOff-label use

Olanzapine (Zyprexa®)Off-label useFDA approved for acute manic and mixed episodes (as monotherapy and adjunct to lithium or valproate)FDA approved

Olanzapine-fluoxetine combination (Symbyax®)FDA approvedOff-label use

Oxcarbazepine (Trileptal®)Off-label useOff-label useOff-label use

Paliperidone (Invega®)Off-label useOff-label use

Paliperidone palmitate (Invega® Sustenna®)Off-label use

Quetiapine fumarate (Seroquel®, Seroquel XR®)FDA approvedFDA approved for acute manic and mixed episodes associated with bipolar I disorder (as monotherapy and adjunct to lithium or divalproex)FDA approved for patients with bipolar I disorder (as adjunct to lithium or divalproex)

Risperidone (Risperdal®)Off-label useFDA approved for acute manic and mixed episodes (as monotherapy and adjunct to lithium or valproate)Off-label use
(Risperdal® Consta®)FDA approved for bipolar I disorder (as monotherapy and adjunct to lithium or valproate)

Thioridazine (Mellaril®)Off-label useOff-label use

Topiramate (Topamax®)Off-label use

Trifluoperazine (Stelazine®)Off-label useOff-label use

Ziprasidone (Geodon®)Off-label useFDA approved for acute manic and mixed episodesFDA approved for patients with bipolar I disorder as adjunct to lithium or valproate

Antidepressant agents (various)Off-label usea
Maprotiline (Ludiomil®)FDA approved
Authors

10.3928/02793695-20190425-79

Sign up to receive

Journal E-contents