Journal of Psychosocial Nursing and Mental Health Services

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Drugs to Treat Overweight and Obesity

Abstract

Table

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Generic (Brand) NameFDA Approval for Weight LossLevel of Evidencea
SYMPATHOMIMETIC DRUGS
Amantadine (Symmetrel®)NoPlacebo-controlled and open-label studies showed efficacy
Benzphetamine (Didrex®)YesRandomized placebo-controlled studies showed efficacy
Diethylpropion (Tenuate®)YesRandomized placebo-controlled studies showed efficacy
Mazindol (Mazanor®, Sanorex®)YesRandomized placebo-controlled studies showed efficacy
Methamphetamine (Desoxyn®)YesRandomized placebo-controlled studies showed efficacy
Modafinil (Provigil®)No (off-label)Placebo-controlled and open-label studies showed efficacy
Phendimetrazine (Bontril PDM®, Bontril SR®, Melfiat®, Obezine®, Phendiet®, Prelu-2®)YesRandomized placebo-controlled studies showed efficacy
Phentermine (Adipex-P®, Lomaira®)YesRandomized placebo-controlled studies showed efficacy
ANTIDEPRESSANT DRUGS
Atomoxetine (Strattera®)No (off-label)Placebo-controlled studies showed efficacy
Bupropion (Forfivo XL®, Wellbutrin®, Wellbutrin SR®, Wellbutrin XL®)No (off-label)Non-placebo–controlled and open-label studies showed efficacy
Milnacipran (Savella®)No (off-label)Placebo-controlled studies showed weight loss in fibromyalgia
SEROTONIN AGONIST DRUGS
Lorcaserin (Belviq®)YesRandomized placebo-controlled studies showed efficacy
ANTICONVULSANT DRUGS
Topiramate (Topamax®)No (off-label)Placebo-controlled; non-placebo–controlled, and open-label studies showed efficacy
Zonisamide (Zonegran®)No (off-label)Non-placebo–controlled studies showed efficacy
HISTAMINE-MODULATING DRUGS
Famotidine (Pepcid®)No (off-label)Placebo-controlled studies did not show efficacy
Nizatidine (Axid®)No (off-label)Mixed results in placebo-controlled studies; open-label studies showed efficacy
Ranitidine (Zantac®)No (off-label)Open-label studies showed efficacy
ANTI-DIABETIC DRUGS
Caragliflozin (Invokana®)No (off-label)Placebo-controlled studies in diabetic obesity
Dapagliflozin (Farxiga®)No (off-label)Placebo-controlled studies in diabetic obesity
Dapagliflozin/metformin (Xigdue XR®)No (off-label)Placebo-controlled studies in diabetic obesity
Empagliflozin (Jardiance®)No (off-label)Placebo-controlled studies in diabetic obesity
Empagliflozin/metformin (Synjardy®)No (off-label)Placebo-controlled studies in diabetic obesity
Exenatide (Bydureon®, Byetta®)No (off-label)Placebo-controlled studies in diabetic and nondiabetic obesity
Liraglutide (Saxenda®)YesPositive placebo-controlled studies in obesity with weight-related medical conditions
Metformin (Glucophage®)No (off-label)Mixed results in placebo-controlled studies; open-label studies showed efficacy
Pramlintide (Symlin®)No (off-label)Placebo-controlled studies in diabetic and nondiabetic obesity
Rosiglitazone (Avandia®)No (off-label)Placebo-controlled studies did not show efficacy
GASTROINTESTINAL DRUGS
Orlistat (Alli®, Xenical®)YesRandomized placebo-controlled studies and open-label studies showed efficacy
COMBINATION THERAPIES
Naltrexone SR/bupropion SR (Contrave®)YesRandomized placebo-controlled studies showed efficacy
Phentermine/topiramate extended-release (Qsymia®)YesRandomized placebo-controlled studies showed efficacy
OTHER DRUGS
MelatoninNo (off-label)Placebo-controlled studies showed attenuated psychotropic drug-related weight gain
Authors

10.3928/02793695-20180629-79

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