Journal of Psychosocial Nursing and Mental Health Services

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FDA-Approved Drugs to Treat Schizophrenia

Abstract

Table

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Generic (Brand) NameIndicationsFormulationsNotable Side Effects
ATYPICAL ANTIPSYCHOTIC DRUGSa

Aripiprazole (Abilify®)Schizophrenia, acute agitationTablet, orally disintegrating tablet, short-acting intramuscular injectionDizziness, insomnia, akathisia, activation, nausea, vomiting, sedation
(Abilify Discmelt®)SchizophreniaOrally disintegrating tablet
(Abilify Maintena®)SchizophreniaLong-acting intramuscular injection
(Aristada®)SchizophreniaLong-acting intramuscular injectionMay increase risk for weight gain, seizures

Asenapine (Saphris®)SchizophreniaOrally disintegrating tabletEPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia

Brexipiprazole (Rexulti®)SchizophreniaTabletMay increase risk of suicidal thoughts and behaviors, weight gain

Cariprazine (Vraylar®)SchizophreniaCapsuleMay increase risk of extrapyramidal symptoms, akathisia, dyspepsia, vomiting, somnolence, restlessness

Clozapine (Clozaril®, Leponex®)Treatment-resistant schizophrenia, suicidal behavior associated with schizophreniaTablet, orally disintegrating tabletIncreased salivation (possibly severe), sweating, agranulocytosis, sedation, weight gain, constipation, hypotension, seizures

Iloperidone (Fanapt®)SchizophreniaTabletEPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia, prolongation of QTc interval

Lurasidone (Latuda®)SchizophreniaTabletEPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia

Olanzapine (Zyprexa®)Schizophrenia, acute agitationTablet, orally disintegrating tablet, short-acting intramuscular injectionSedation, weight gain, hyperprolactinemia, constipation, hypotension, seizures
(Zyprexa® Relprevv)SchizophreniaLong-acting intramuscular injection
(Zyprexa® Zydis®)SchizophreniaOrally disintegrating tablet

Paliperidone (Invega®)Schizophrenia, schizoaffective disorderTabletEPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, tachycardia, headache
(Invega® Sustenna®, Trinza®)SchizophreniaLong-acting intramuscular injection

Quetiapine (Seroquel®, Seroquel® XR)SchizophreniaTabletDizziness, sedation, weight gain, constipation, hypotension, prolongation of QTc interval

Risperidone (Risperdal®)SchizophreniaTablet, orally disintegrating tablet, oral solution, long-acting intramuscular injectionEPS (dosage dependent), hyperprolactinemia (dosage dependent), sedation, weight gain, akathisia
(Risperdal® Consta®)SchizophreniaLong-acting intramuscular injection
(Risperdal® M-Tab®)SchizophreniaOrally disintegrating tablet

Ziprasidone (Geodon®)Schizophrenia, acute agitationCapsule, short-acting intramuscular injectionPossible activating side effects at very low to low dosages, sedation, hypotension, akathisia, prolongation of QTc interval

CONVENTIONAL ANTIPSYCHOTIC DRUGSa

Chlorpromazine (Thorazine®)Schizophrenia, acute agitationTablet, capsule, oral solution, suppository, short-acting intramuscular injectionAkathisia, EPS, sedation, weight gain, hypotension, constipation, hyperprolactinemia, photosensitivity, prolongation of QTc interval

Fluphenazine (Prolixin®)SchizophreniaTablet, oral concentrate, oral elixir, short-acting intramuscular injection, long-acting intramuscular injectionSedation, weight gain, hyperprolactinemia, EPS, akathisia, dystonia

Haloperidol (Haldol®)Schizophrenia, acute agitationTablet, oral concentrate, short-acting intramuscular injection, long-acting intramuscular injectionAkathisia, EPS, dystonia, sedation, hypotension, constipation, hyperprolactinemia, prolongation of QTc interval

Loxapine (Loxitane®)SchizophreniaCapsule, oral concentrate, short-acting intramuscular injectionAkathisia, EPS, sedation, hypotension, constipation, hyperprolactinemia, dystonia
(Adasuve®)Schizophrenia, acute agitationInhalation powderAltered taste, sedation

Molindone (Moban®)SchizophreniaTabletAkathisia, EPS, sedation, constipation, hyperprolactinemia, dystonia

Perphenazine (Trilafon®)SchizophreniaTablet, oral concentrate, short-acting intramuscular injectionAkathisia, EPS, sedation, weight gain, hypotension, constipation, hyperprolactinemia, dystonia

Pimozide (Orap®)SchizophreniabTabletSedation, constipation, hypotension, hyperprolactinemia, EPS, akathisia, dystonia

Prochlorperazine (Compazine®)SchizophreniaTablet, suppository, short-acting intramuscular injectionHypotension, hyperprolactinemia, EPS, akathisia, dystonia

Thioridazine (Mellaril®)SchizophreniaTablet, oral concentrateAkathisia, EPS, pigmentary retinopathy (at high dosages), sedation, weight gain, hypotension, constipation, hyperprolactinemia, dystonia, prolongation of QTc interval

Thiothixene (Navane®)SchizophreniaCapsule, short-acting intramuscular injectionAkathisia, EPS, sedation, hypotension, constipation, hyperprolactinemia, dystonia

Trifluoperazine (Stelazine®)SchizophreniaTablet, oral concentrate, short-acting intramuscular injectionAkathisia, EPS, sedation, hypotension, constipation, hyperprolactinemia, dystonia
Authors

10.3928/02793695-20171026-79

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