Journal of Psychosocial Nursing and Mental Health Services

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Drugs to Treat Overweight and Obesity

Abstract

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

Generic (Brand) NameFDA Approval for Weight LossLevel of Evidencea
SYMPATHOMIMETIC DRUGS
Amantadine (Symmetrel®)NoPositive placebo-controlled studies; open-label studies
Amphetamine (Adderall® and others)NoNo studies
Armodafinil (Nuvigil®)NoNo studies
Benzphetamine (Didrex®)YesNo studies
Bromocriptine mesylate (Parlodel®)NoNo studies
Diethylpropion (Tenuate®)YesNo studies
Ephedrine plus caffeineNoNo studies
Mazindol (Mazanor®, Sanorex®)YesNo studies
Methamphetamine (Desoxyn®)YesNo studies
Methylphenidate (Ritalin® and others)NoNo studies
Modafinil (Provigil®)NoPositive placebo-controlled studies; open-label studies
Phendimetrazine (Bontril PDM®, Bontril SR®, Melfiat®, Obezine®, Phendiet®, Prelu-2®)YesNo studies
Phentermine (Fastin®)YesNo studies
ANTIDEPRESSANT DRUGS
Atomoxetine (Strattera®)NoPositive placebo-controlled studies
Bupropion (Forfivo XL®, Wellbutrin®, Wellbutrin SR®, Wellbutrin XL®)NoNon-placebo-controlled studies; open-label studies
Desipramine (Norpramin®)NoNo studies
Desvenlafaxine (Pristiq®)NoNo studies
Duloxetine (Cymbalta®)NoNo studies
Nortriptyline (Aventyl®, Pamelor®)NoNo studies
Protriptyline (Vivactil®)NoNo studies
Venlafaxine (Effexor®, Effexor XR®)NoNo studies
SEROTONIN AGONIST DRUGS
Lorcaserin (Belviq®)YesPositive placebo-controlled studies
ANTICONVULSANT DRUGS
Topiramate (Topamax®)NoPositive placebo-controlled studies; non-placebo-controlled studies; open-label studies
Zonisamide (Zonegran®)NoNon-placebo-controlled studies
HISTAMINE-MODULATING DRUGS
Famotidine (Pepcid®)NoNegative placebo-controlled studies
Nizatidine (Axid®)NoPositive placebo-controlled studies; open-label studies; negative placebo-controlled studies
Ranitidine (Zantac®)NoOpen-label studies
ANTI-DIABETIC DRUGS
Exenatide (Bydureon®, Byetta®)NoPlacebo-controlled studies in diabetic obesity and in nondiabetic obesity
Liraglutide (Victoza®)NoPositive placebo-controlled studies in diabetic obesity
Metformin (Glucophage®)NoPositive placebo-controlled studies; open-label studies; negative placebo-controlled studies
Pramlintide (Symlin®)NoPlacebo-controlled studies in diabetic obesity and in nondiabetic obesity
Rosiglitazone (Avandia®)NoNegative placebo-controlled studies
GASTROINTESTINAL DRUGS
Orlistat (Alli®, Xenical®)YesPositive placebo-controlled studies; open-label studies; negative placebo-controlled studies
COMBINATION THERAPIES
Naltrexone SR/bupropion SRbNoPositive placebo-controlled studies
Phentermine/topiramate extended-release(Qsymia®)YesPositive placebo-controlled studies

10.3928/02793695-20140702-79

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