Journal of Psychosocial Nursing and Mental Health Services

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Drugs to Treat Overweight and Obesity

Abstract

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

Generic (Brand) Name FDA Approval for Weight Loss Level of Evidencea
SYMPATHOMIMETIC DRUGS
Amantadine (Symmetrel®) No Positive placebo-controlled studies; open-label studies
Amphetamine (Adderall® and others) No No studies
Armodafinil (Nuvigil®) No No studies
Benzphetamine (Didrex®) Yes No studies
Bromocriptine mesylate (Parlodel®) No No studies
Diethylpropion (Tenuate®) Yes No studies
Ephedrine plus caffeine No No studies
Mazindol (Mazanor®, Sanorex®) Yes No studies
Methamphetamine (Desoxyn®) Yes No studies
Methylphenidate (Ritalin® and others) No No studies
Modafinil (Provigil®) No Positive placebo-controlled studies; open-label studies
Phendimetrazine (Bontril PDM®, Bontril SR®, Melfiat®, Obezine®, Phendiet®, Prelu-2®) Yes No studies
Phentermine (Fastin®) Yes No studies
ANTIDEPRESSANT DRUGS
Atomoxetine (Strattera®) No Positive placebo-controlled studies
Bupropion (Forfivo XL®, Wellbutrin®, Wellbutrin SR®, Wellbutrin XL®) No Non-placebo-controlled studies; open-label studies
Desipramine (Norpramin®) No No studies
Desvenlafaxine (Pristiq®) No No studies
Duloxetine (Cymbalta®) No No studies
Nortriptyline (Aventyl®, Pamelor®) No No studies
Protriptyline (Vivactil®) No No studies
Venlafaxine (Effexor®, Effexor XR®) No No studies
ANTICONVULSANT DRUGS
Topiramate (Topamax®) No Positive placebo-controlled studies; non-placebo-controlled studies; open-label studies
Zonisamide (Zonegran®) No Non-placebo-controlled studies
HISTAMINE-MODULATING DRUGS
Famotidine (Pepcid®) No Negative placebo-controlled studies
Nizatidine (Axid®) No Positive placebo-controlled studies; open-label studies; negative placebo-controlled studies
Ranitidine (Zantac®) No Open-label studies
ANTI-DIABETIC DRUGS
Exenatide (Bydureon®, Byetta®) No Placebo-controlled studies in diabetic obesity and in nondiabetic obesity
Liraglutide (Victoza®) No Positive placebo-controlled studies in diabetic obesity
Metformin (Glucophage®) No Positive placebo-controlled studies; open-label studies; negative placebo-controlled studies
Pramlintide (Symlin®) No Placebo-controlled studies in diabetic obesity and in nondiabetic obesity
Rosiglitazone (Avandia®) No Negative placebo-controlled studies
GASTROINTESTINAL DRUGS
Orlistat (Alli®, Xenical®) Yes Positive placebo-controlled studies; open-label studies; negative placebo-controlled studies
COMBINATION THERAPIES
Naltrexone SR/bupropion SRb No Positive placebo-controlled studies
Phentermine/topiramate extended-release (Qsymia®) Yes Positive placebo-controlled studies

10.3928/02793695-20130709-79

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