Journal of Psychosocial Nursing and Mental Health Services

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Clinical Uses of Anticonvulsant Drugs Other Than for Epilepsy

Abstract

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

A handy source of up-to-date information on current medications for psychiatric illnesses

Table

Generic (Brand) NameClinical Uses Other Than EpilepsyLevel of Evidence

Acetazolamide (Diamox®)Bipolar disorderOpen-label studies
Tardive dyskinesiaPositive placebo-controlled studies

Carbamazepine (Equetro®, Tegretol®, and others)Aggression/agitation; benzodiazepine withdrawal; cocaine cravingPositive placebo-controlled studies; open-label studies; negative placebo-controlled studies
Alcohol cravingPositive placebo-controlled studies
Alcohol withdrawal; bipolar disorder; pain; panic disorder; unipolar depressionPositive placebo-controlled studies; open-label studies
PTSDOpen-label studies

Clonazepam (Klonopin®)Alcohol withdrawal; anxiety; insomniaOpen-label studies
Panic disorderPositive placebo-controlled studies

Clorazepate (Tranxene®)Alcohol withdrawalPositive placebo-controlled studies; open-label studies
AnxietyPositive placebo-controlled studies; non-placebo-controlled studies
InsomniaPositive placebo-controlled studies
Panic disorderNon-placebo-controlled studies
Tardive dyskinesiaOpen-label studies

Diazepam (Valium®)Alcohol withdrawal; panic disorderPositive placebo-controlled studies
Anxiety; insomniaOpen-label studies

Gabapentin (Neurontin®)Aggression/agitation; anxiety; PTSD; tardive dyskinesiaOpen-label studies
Alcohol withdrawalNon-placebo-controlled studies; open-label studies; negative placebo-controlled studies
Bipolar disorder; cocaine cravingOpen-label studies; negative placebo-controlled studies
InsomniaNon-placebo-controlled studies; open-label studies
Panic disorder; social anxiety disorderPositive placebo-controlled studies

Lacosamide (Vimpat®)Diabetic neuropathic painPositive placebo-controlled studies

Lamotrigine (Lamictal®, Lamictal XR®)Bipolar depression; painPositive placebo-controlled studies; open-label studies; negative placebo-controlled studies
Bipolar disorder maintenance; obesityPositive placebo-controlled studies; open-label studies
Cocaine craving; unipolar depressionNon-placebo-controlled studies; open-label studies
PTSDOpen-label studies
SchizophreniaPositive placebo-controlled studies; negative placebo-controlled studies

Levetiracetam (Keppra®, Keppra XR®)Alcohol withdrawal; anxiety; bipolar mania; bipolar depression; panic disorder; PTSD; tardive dyskinesiaOpen-label studies
Social anxiety disorderOpen-label studies; negative placebo-controlled studies

Oxcarbazepine (Trileptal®)ADHD; benzodiazepine withdrawalOpen-label studies
Aggression/agitationPositive placebo-controlled studies; open-label studies
Alcohol cravingNon-placebo-controlled studies; open-label studies
Alcohol withdrawal; bipolar disorderOpen-label studies; negative placebo-controlled studies
PainPositive placebo-controlled studies; open-label studies; negative placebo-controlled studies

Phenobarbital (Luminal®)Alcohol withdrawalNon-placebo-controlled studies; open-label studies
Anxiety; barbiturate withdrawal; insomniaOpen-label studies
Benzodiazepine withdrawalNon-placebo-controlled studies

Phenytoin (Dilantin®, Phenytek®)Alcohol withdrawal seizures; bipolar disorder; chronic painPositive placebo-controlled studies

Pregabalin (Lyrica®)Benzodiazepine withdrawal; insomniaOpen-label studies
Generalized anxiety disorder; painPositive placebo-controlled studies; open-label studies
Social anxiety disorderPositive placebo-controlled studies

Primodone (Mysoline®)Bipolar maniaOpen-label studies

Tiagabine (Gabitril®)Alcohol withdrawal; depression; pain; social anxiety disorderOpen-label studies
Cocaine cravingPositive placebo-controlled studies; negative placebo-controlled studies
Generalized anxiety disorder; insomnia; PTSDOpen-label studies; negative placebo-controlled studies

Topiramate (Topamax®)Alcohol cravingPositive placebo-controlled studies; non-placebo-controlled studies; open-label studies
Binge eating disorderOpen-label studies
Bipolar disorderOpen-label studies; negative placebo-controlled studies
Bulimia; obesityPositive placebo-controlled studies; open-label studies

Valproic acid (Depakene®), valproic acid delayed release (Stavzor®), divalproex sodium delayed release (Depakote®), divalproex sodium extended release (Depakote ER®), valproate sodium injectable (Depacon®)Aggression/agitation; generalized anxiety disorder; panic disorder; PTSD; social anxiety disorderOpen-label studies
Alcohol withdrawalNon-placebo-controlled studies
Bipolar disorder; bipolar depressionPositive placebo-controlled studies; open-label studies

Zonisamide (Zonegran®)Binge eating disorder; obesityPositive placebo-controlled studies; open-label studies
Bipolar disorder; bipolar depressionOpen-label studies

10.3928/02793695-20120718-70

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