Results of a 12-week, head-to-head, Phase III study published in Hypertension found systolic blood pressure (SBP) reductions of a fixed-dose combination of azilsartan medoxomil and chlorthalidone (Edarbyclor®) 40/25 mg were statistically superior to those of the fixed-dose combination of olmesartan medoxomil-hydrochlorothiazide (Benicar®) 40/25 mg. Edarbyclor is the first and only hypertension medication to combine an angiotensin II receptor blocker with chlorthalidone, a diuretic, in a once-daily, single tablet.
Results after 12 weeks of treatment showed that the fixed-dose combination of Edarbyclor 40/25 mg reduced clinic SBP by 42.5 mm Hg from baseline. The reductions were statistically significantly (p < 0.001) greater than that of the fixed-dose combination of Benicar 40/25 mg (37.1 mm Hg). Similar results were observed across patient subgroups, including age, sex, and race.
The study sample included 1,071 patients with mean baseline clinic SBPs ranging from 160 to 190 mm Hg and diastolic blood pressures equal to or lower than 119 mm Hg. Two Edarbyclor fixed-dose combination groups were force titrated from 20/12.5 mg and 40/12.5 mg to 40/25 mg and 80/25 mg, respectively. In the Benicar fixed-dose combination group, patients were force titrated from 20/12.5 mg to 40/25 mg, the highest approved dose. The primary endpoint was change from baseline to Week 12 in trough (measured approximately 24 hours after the last treatment dose) clinic SBP, with changes in 24-hour ambulatory blood pressure monitoring as secondary endpoints.
After 12 weeks, Edarbyclor lowered blood pressure more effectively than Benicar at each hour of the 24-hour period between doses.
Source.“Edarbyclor (azilsartan medoxomil and chlorthalidone) Head-to-Head Data Published in Hypertension.” (2012, June 19). Retrieved August 8, 2012, from http://www.tpna.com/newsroom/press_release_detail.aspx?year=2012&id=243.
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Source.“Journey To Botanicals Launches Natural Remedy for Stress and Anxiety.” (2012, June 19). Retrieved August 8, 2012, from the PR Newswire website: http://s.tt/1f6hl.…