Tamoxifen — a drug commonly used for breast cancer — shows potential as a treatment for episodes of mania in patients with bipolar disorder, according to a systematic review and meta-analysis published in Journal of Psychopharmacology.

Other than lithium, all FDA-approved bipolar disorder treatments were first developed for other indications, according to Jorge Palacios, MD, PhD, from the Institute of Psychiatry, Psychology & Neuroscience, King’s College London, and colleagues.