A hard stop clinical decision support tool embedded in the electronic medical record significantly reduced repeat Clostridioides difficile toxin enzyme immunoassay, or T-EIA, testing at a hospital in St. Louis.
“Due to concern regarding the low sensitivity of toxin T-EIA tests, a common misconception exists that three sequential tests are necessary to ‘rule out’ [C. difficile infection (CDI)],” Jennie H. Kwon, DO, MSCI, assistant professor of medicine in the division of infectious diseases at Washington University School of Medicine, and colleagues wrote. “This practice has led to a decrease in the positive predictive value of each subsequent test and, therefore, to an increase in the likelihood of false-positive results.”
This activity is supported by an educational grant from Genentech, Inc.
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