ATLANTA — Patients with juvenile dermatomyositis demonstrate obvious mitochondrial abnormalities in the tissue and periphery, supporting the use of anti-mitochondrial antibodies as a prognostic marker, according to data presented at ACR/ARP 2019.
“Though mainly found intracellularly, we recently observed mitochondrial extrusion upon cell death, contributing to inflammation and organ damage in lupus-prone mice,” Christian Lood, PhD, MSc, of the University of Washington in Seattle, told attendees. “Of note, mitochondria are immunogenic, promoting development of anti-mitochondrial antibodies. Mitochondrial remnants, including DNA, are observed in the circulation of many systemic diseases, including lupus, and thought to partake in the disease pathogenesis. However, the role of mitochondrial extrusion in children with juvenile dermatomyositis has not been addressed.”
This activity is supported by an educational grant from Merck & Co., Inc.
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