Pediatric Annals

CME QUIZ

Abstract

INSTRUCTIONS

Pediatricians may receive three credit hours in Category 1 for the Physician's Recognition Award of the American Medical Association by reading the material in this issue and successfully answering the questions in the quiz below. To obtain credits, follow these instructions.

1. Read each of the articles carefully. Oo not neglect the tables and other illustrative materiafs, as they have been selected to enhance your knowledge and understanding.

2. The following questions have been designed to provide a useful link between the articles in the issue and your everyday practice. Read each question, choose the correct answer, and record your answer on the CME Registration Form at the end of the quiz. Retain a copy of your answers so that they can be compared with the correct answers that will be sent to you later.

3. Type or print your full name and address and your Social Security number in the spaces provided on the CME Registration Form.

4. Send the completed form, with your check or money order for S 1 5 made out to PEDIATRIC ANNALS CME CENTER. 6900 Grove Road. Thorofare. NJ. 0808b.

5. Your answers will be graded, and you will be advised that you have passed (or failed). An answer sheet containing all correct answers will be mailed to you. Review the parts of the articles dealing with any questions you have missed, and read the supplemental material on this aspect of the subject listed in the references in this issue.

6. Be sure to mall the form on or before the deadline listed on the CME Registration Form, so that credit can be awarded. IAfter that date, the quiz will close, and correct answers will appear in the magazine.) Unanswered questions will be considered incorrect and so scored. A minimum score of 70 must be obtained in order for credits to be awarded.

CERTIFYING INSTITUTION

As an organization accredited for continuing medical education, the Lexon Hill Hospital of New York designates this continuing medical education activity as meeting the criteria for three credit hours in Category I for Educational Materials for the Physician's Recognition Award of the American Medicai Association, provided it has been completed according to instructions."

CME Quiz

Pediatric Immunology II

1. An Ig molecule is composed of two identical heavy chains and two identical light chains.

A. True

B. False

2. The light chains of an Ig molecule are twice as long as the heavy chains.

A. True

B. False

3. The actual binding of antigens Is done by the:

A. variable light domain (V^sub J^ + constant light domain (C^sub L^).

B. variable heavy domain (V^sub H^) + constant light domain (C^sub L^).

C. variable heavy domain (V^sub H^) + variable light domain (V^sub L^).

D. constant light domain (C^sub L^) + constant heavy domain (C^sub H^).

4. The antigen-presenting cell is necessary to:

A. secrete Interleukin 4.

B. focus antigen on the cell surface in the context of Iv)HC class Il molecules and in a form which is maximally stimulatory for T cel/s.

C. kill the pathogen before the other immune cells are exposed to it.

D. all of the above.

5. The only cell which Is not committed to a single antigen specificity prior to entry of antigen Into the system Is:

A. T cell.

B. B cell.

C. mononuclear phagocyte.

D. none of the above.

6. The only cell surface molecule which is required In order to confer antigen-presenting function on a fibroblast Is:

A. fibronectin.

B. calmodulin.

C. protein kinase c.

D. MHC class Il molecules.

7. T cells cross-react with unfolded forms of native…

INSTRUCTIONS

Pediatricians may receive three credit hours in Category 1 for the Physician's Recognition Award of the American Medical Association by reading the material in this issue and successfully answering the questions in the quiz below. To obtain credits, follow these instructions.

1. Read each of the articles carefully. Oo not neglect the tables and other illustrative materiafs, as they have been selected to enhance your knowledge and understanding.

2. The following questions have been designed to provide a useful link between the articles in the issue and your everyday practice. Read each question, choose the correct answer, and record your answer on the CME Registration Form at the end of the quiz. Retain a copy of your answers so that they can be compared with the correct answers that will be sent to you later.

3. Type or print your full name and address and your Social Security number in the spaces provided on the CME Registration Form.

4. Send the completed form, with your check or money order for S 1 5 made out to PEDIATRIC ANNALS CME CENTER. 6900 Grove Road. Thorofare. NJ. 0808b.

5. Your answers will be graded, and you will be advised that you have passed (or failed). An answer sheet containing all correct answers will be mailed to you. Review the parts of the articles dealing with any questions you have missed, and read the supplemental material on this aspect of the subject listed in the references in this issue.

6. Be sure to mall the form on or before the deadline listed on the CME Registration Form, so that credit can be awarded. IAfter that date, the quiz will close, and correct answers will appear in the magazine.) Unanswered questions will be considered incorrect and so scored. A minimum score of 70 must be obtained in order for credits to be awarded.

CERTIFYING INSTITUTION

As an organization accredited for continuing medical education, the Lexon Hill Hospital of New York designates this continuing medical education activity as meeting the criteria for three credit hours in Category I for Educational Materials for the Physician's Recognition Award of the American Medicai Association, provided it has been completed according to instructions."

CME Quiz

Pediatric Immunology II

1. An Ig molecule is composed of two identical heavy chains and two identical light chains.

A. True

B. False

2. The light chains of an Ig molecule are twice as long as the heavy chains.

A. True

B. False

3. The actual binding of antigens Is done by the:

A. variable light domain (V^sub J^ + constant light domain (C^sub L^).

B. variable heavy domain (V^sub H^) + constant light domain (C^sub L^).

C. variable heavy domain (V^sub H^) + variable light domain (V^sub L^).

D. constant light domain (C^sub L^) + constant heavy domain (C^sub H^).

4. The antigen-presenting cell is necessary to:

A. secrete Interleukin 4.

B. focus antigen on the cell surface in the context of Iv)HC class Il molecules and in a form which is maximally stimulatory for T cel/s.

C. kill the pathogen before the other immune cells are exposed to it.

D. all of the above.

5. The only cell which Is not committed to a single antigen specificity prior to entry of antigen Into the system Is:

A. T cell.

B. B cell.

C. mononuclear phagocyte.

D. none of the above.

6. The only cell surface molecule which is required In order to confer antigen-presenting function on a fibroblast Is:

A. fibronectin.

B. calmodulin.

C. protein kinase c.

D. MHC class Il molecules.

7. T cells cross-react with unfolded forms of native proteins and with antigenic peptides because of:

A. lack of specificity of the T cell receptor for antigen.

B. requirement for antigen processing to unfold the antigen and to open up sites for MHC class Il association and T celi recognition.

C. both A and B.

D. none of the above.

8. Future vaccines may be made of synthetic viral components such as synthetic peptides corresponding to the sequence of some viral protein, or recombinant DNA constructs such as hybrid viruses, which express the recombinant antigen In addition to their own proteins. The requirements for synthetic vaccines include:

A. ability to interact with a wide variety of human MHC class Il molecules in order to be immunogenic for the entire population.

B. ability to elicit a T cell response.

C. ability to elicit neutralizing antibodies.

D. all of the above.

9. The pathway of the complement system activated by specific antigen-antibody binding Is the:

A. alternative pathway

B. feedback amplification loop.

C. classical pathway

D. membrane attack complex.

10. Mechanisms by which control is exerted on complement reactions Include:

A. decay/dissociation.

B. replacement of crucial proteins in an enzyme complex.

C. enzymatic cleavage.

D. all of the above.

11. A complete analysis of the complement system might include assessment of:

A. functional activity

B. activation status.

C. quantitation of individual complement components.

D. all of the above.

12. Complement component deficiencies have been associated with:

A. recurrent infections.

B. short stature.

C. autoimmune diseases.

D. A and C

13. Most lymphokine-activated killer (LAKj cells are associated with:

A. cytotoxic T cells (CTL).

B. natural killer (NK) cells.

C. monocytes or macrophages.

D. none of the above.

14. NK cells have the morphology of:

A small lymphocytes.

B. monocytes.

C. large granular lymphocytes.

D. none of the above.

15. Interferon has been shown to be potent In the augmentation of NK cell activity.

A. True

B. False

16. The activities of the effector cells (CTL and NK) and the target cells which lead to cytotoxicity involve all except one of the following steps. Which one is incorrect?

A. Recognition of target cells by effector cells.

B. Binding of effectors to target cells.

C. Lytic effect on target cells.

D. Absorption of target cells by effector cells.

17. NK cells upon binding to the target cells are triggered to release granule-associated cytolysin which kills the target cells.

A. True

B. False

18. The onset of symptoms In children infected with AIDS neonatally is:

A at birth.

B. between 4 and 6 months of age.

C. at 6 years of age.

D. at 12 years of age.

19. The clinical signs of immunodeficiency in the pediatric population consist of:

A. thrombocytopenia.

B. failure to thrive.

C. both A and B.

20. The HlV Invades the host's T cells causing the T cells' death and releasing the virus to spread to other T cells. The virus also acts directly on:

A. polynuclear cells.

B. the complement system.

C. the immunoglobulins.

D. all of the above.

ANSWERS TO THE MARCH QUIZ

Infant Nutrition

1. C

2. D

3. C

4. D

5. C

6. B

7. B

8. D

9. B

10. D

11. A

12. B

13. B

14. D

15. B

16. 0

17. A

18. O

19. C

20. D

10.3928/0090-4481-19870601-12

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