Pediatric Annals

BOOK REVIEWS 

NEUROBLASTOMA: CLINICAL AND BIOLOGICAL MANIFESTATIONS

William A Smithson, MD

Abstract

Carl Pochedly, M.D. (Editor) NEUROBLASTOMA: CLINICAL AND BIOLOGICAL MANIFESTATIONS North Holland, New York: Elsevier, 1982, 315 pp., $49.50

This multi-authored book is another in a series of books on pediatric oncology edited by Carl Pochedly. Like the others, it represents an important contribution to the literature of its topic: neuroblastoma. Dr. Pochedly has drawn from a wide range of contributors to cover both the clinical and basic science foundation for our present concepts and clinical practice. The stronger chapters are those by Gitlow and collaborators on catecholamine metabolism, by Seeger on the immunology of neuroblastoma, by Brodeur on genetics and cytogenetics, and by Machin on histogenesis and histopathology. On the clinical side, the chapter by Jaffe detailing the unpredictable natural course of neuroblastoma in children is particularly useful. An extensive bibliography follows each chapter and along with the index is one of the most valuable aspects of the book.

There is slight inconsistency in staging classifications between the chapters of Bond and Finkelstein and the chapter by Shaw. Presumably, this inconsistency was an editorial oversight. The book is not a handbook of treatment of the various stages and manifestations. Since therapy other than surgery for early stage disease has not been particularly successful in neuroblastoma, it is appropriate that details of therapy are not emphasized. Better understanding of the biology of neuroblastoma will probably be the key to better therapy in the future. This volume furnishes us a compendium of present-day knowledge and will be a useful addition to the libraries of pediatric oncologists and laboratory workers who deal with neuroblastoma. In addition, it should be available as a reference to all with an interest in diseases of children and should be included in every general medical library.…

Carl Pochedly, M.D. (Editor) NEUROBLASTOMA: CLINICAL AND BIOLOGICAL MANIFESTATIONS North Holland, New York: Elsevier, 1982, 315 pp., $49.50

This multi-authored book is another in a series of books on pediatric oncology edited by Carl Pochedly. Like the others, it represents an important contribution to the literature of its topic: neuroblastoma. Dr. Pochedly has drawn from a wide range of contributors to cover both the clinical and basic science foundation for our present concepts and clinical practice. The stronger chapters are those by Gitlow and collaborators on catecholamine metabolism, by Seeger on the immunology of neuroblastoma, by Brodeur on genetics and cytogenetics, and by Machin on histogenesis and histopathology. On the clinical side, the chapter by Jaffe detailing the unpredictable natural course of neuroblastoma in children is particularly useful. An extensive bibliography follows each chapter and along with the index is one of the most valuable aspects of the book.

There is slight inconsistency in staging classifications between the chapters of Bond and Finkelstein and the chapter by Shaw. Presumably, this inconsistency was an editorial oversight. The book is not a handbook of treatment of the various stages and manifestations. Since therapy other than surgery for early stage disease has not been particularly successful in neuroblastoma, it is appropriate that details of therapy are not emphasized. Better understanding of the biology of neuroblastoma will probably be the key to better therapy in the future. This volume furnishes us a compendium of present-day knowledge and will be a useful addition to the libraries of pediatric oncologists and laboratory workers who deal with neuroblastoma. In addition, it should be available as a reference to all with an interest in diseases of children and should be included in every general medical library.

10.3928/0090-4481-19830501-09

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