Meeting News Coverage

Parasitic infection inhibited vaccine response in children from rural Kenya

2011 ASTMH

Parasitic infection inhibited vaccine response in children from rural Kenya

PHILADELPHIA — New data from Kenya indicate that there is an under-recognized burden of parasitism in younger children that may be linked to a decreased response to standard childhood vaccinations, according to a presenter here at the American Society of Tropical Medicine and Hygiene 60th Annual Meeting.

Children are at high risk for soil-transmitted helminths (STHs) and protozoal infections, and these parasitic infections have detrimental effects on weight, height and head circumference growth rates in children aged 0 to 36 months. Certain parasitic infections during childhood may also be linked to decreased response to standard childhood vaccinations, according to results of a study by A. Desiree LaBeaud, MD, MS, of the Children’s Hospital Oakland Research Institute in California, and colleagues.

“Vaccines are among the most cost-effective strategies for infectious disease prevention in the world. But unfortunately, there is a disparity, and children in developing nations are often much less responsive to vaccinations compared with their counterparts in developed nations,” LaBeaud said during a presentation. “While there are many reasons for this, including cold chain issues, infrastructure, HIV/AIDS and malnutrition, chronic parasitic infection plays a role in weakened vaccine response.”

Desiree LaBeaud, MD
Desiree
LaBeaud

To document the prevalence of parasites and their effects on growth and response to childhood vaccines in young children in coastal Kenya, the investigators collected stool, urine and blood samples from children at 6-month intervals until age 3 years and tested for STHs (Ascaris, Trichuris, hookworm and Strongyloides), protozoa (malaria, Giardia) and schistosomiasis. Height, weight and head circumference were measured at each visit. A total of 545 infant–maternal pairs were enrolled in the study that began in 2007, and infections in both mothers and infants were documented.

Of 545 children, 32% were infected with one parasite, and 8% of the children were infected with more than one parasite. Hookworm was the most prevalent STH (11%), followed by Trichuris (10%), Ascaris (4%) and Strongyloides (2%). Giardia was the most prevalent protozoan (13%), followed by malaria (12%). Immunoglobulin G4 testing revealed that 4% of the children had schistosomiasis.

“There are children who have more than one parasitic infection as early as in the first 6 months of life and this polyparasitized proportion increases as the child cohort gets older,” LaBeaud said.

According to LaBeaud, polyparasitized children were more likely to have polyparasitized mothers (P=.006) and have poor HC growth rate (0.002). Children with malaria (P=0.04or Trichuris infection (P=.005) had lower weight z scores, and children with any parasitic infection (P=.01) had lower HC z scores.

All of the children in the study received a complete vaccination series, which includes a pentavalent vaccine (hepatitis B, Haemophilus influenzae type b, tetanus-diphtheria and whole-cell pertussis) and trivalent oral polio vaccine. Pentavalent vaccine was given at 6, 10 and 14 weeks of age, and polio vaccine was given at 0, 6, 10 and 14 weeks of age.

Regarding vaccine response, children with STH had statistically lower tetanus, Hib, and diphtheria titers compared with uninfected children. Children with malaria had statistically lower polio, tetanus, and diphtheria titers.

Response to tetanus, diphtheria, hepatitis B virus, Hib and poliovirus vaccinations were measured by standard enzyme-linked immunosorbent assay (ELISA). McNemar’s test, t test on log-transformed titers and repeated measure modeling were used to analyze data.

Disclosure: Dr. LaBeaud reports no relevant financial disclosures.

For more information:

Twitter Follow the PediatricSuperSite.com on Twitter.

2011 ASTMH

Parasitic infection inhibited vaccine response in children from rural Kenya

PHILADELPHIA — New data from Kenya indicate that there is an under-recognized burden of parasitism in younger children that may be linked to a decreased response to standard childhood vaccinations, according to a presenter here at the American Society of Tropical Medicine and Hygiene 60th Annual Meeting.

Children are at high risk for soil-transmitted helminths (STHs) and protozoal infections, and these parasitic infections have detrimental effects on weight, height and head circumference growth rates in children aged 0 to 36 months. Certain parasitic infections during childhood may also be linked to decreased response to standard childhood vaccinations, according to results of a study by A. Desiree LaBeaud, MD, MS, of the Children’s Hospital Oakland Research Institute in California, and colleagues.

“Vaccines are among the most cost-effective strategies for infectious disease prevention in the world. But unfortunately, there is a disparity, and children in developing nations are often much less responsive to vaccinations compared with their counterparts in developed nations,” LaBeaud said during a presentation. “While there are many reasons for this, including cold chain issues, infrastructure, HIV/AIDS and malnutrition, chronic parasitic infection plays a role in weakened vaccine response.”

Desiree LaBeaud, MD
Desiree
LaBeaud

To document the prevalence of parasites and their effects on growth and response to childhood vaccines in young children in coastal Kenya, the investigators collected stool, urine and blood samples from children at 6-month intervals until age 3 years and tested for STHs (Ascaris, Trichuris, hookworm and Strongyloides), protozoa (malaria, Giardia) and schistosomiasis. Height, weight and head circumference were measured at each visit. A total of 545 infant–maternal pairs were enrolled in the study that began in 2007, and infections in both mothers and infants were documented.

Of 545 children, 32% were infected with one parasite, and 8% of the children were infected with more than one parasite. Hookworm was the most prevalent STH (11%), followed by Trichuris (10%), Ascaris (4%) and Strongyloides (2%). Giardia was the most prevalent protozoan (13%), followed by malaria (12%). Immunoglobulin G4 testing revealed that 4% of the children had schistosomiasis.

“There are children who have more than one parasitic infection as early as in the first 6 months of life and this polyparasitized proportion increases as the child cohort gets older,” LaBeaud said.

According to LaBeaud, polyparasitized children were more likely to have polyparasitized mothers (P=.006) and have poor HC growth rate (0.002). Children with malaria (P=0.04or Trichuris infection (P=.005) had lower weight z scores, and children with any parasitic infection (P=.01) had lower HC z scores.

All of the children in the study received a complete vaccination series, which includes a pentavalent vaccine (hepatitis B, Haemophilus influenzae type b, tetanus-diphtheria and whole-cell pertussis) and trivalent oral polio vaccine. Pentavalent vaccine was given at 6, 10 and 14 weeks of age, and polio vaccine was given at 0, 6, 10 and 14 weeks of age.

Regarding vaccine response, children with STH had statistically lower tetanus, Hib, and diphtheria titers compared with uninfected children. Children with malaria had statistically lower polio, tetanus, and diphtheria titers.

Response to tetanus, diphtheria, hepatitis B virus, Hib and poliovirus vaccinations were measured by standard enzyme-linked immunosorbent assay (ELISA). McNemar’s test, t test on log-transformed titers and repeated measure modeling were used to analyze data.

Disclosure: Dr. LaBeaud reports no relevant financial disclosures.

For more information:

Twitter Follow the PediatricSuperSite.com on Twitter.

    See more from American Society of Tropical Medicine and Hygiene (ASTMH)