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Serum biomarker levels linked with chondroitin sulfate treatment response in knee OA with cartilage loss

July 21, 2017

Serum biomarker levels were linked with treatment response to chondroitin sulfate in knees with osteoarthritis cartilage loss, according to a recently published study.

“Although this study is exploratory and should be replicated with a larger number of patients to fully confirm the findings, data indicate that higher baseline values of the biomarkers related to collagen metabolism, [N-terminal propeptide of collagen II alpha] PIIANP and [C-terminal crosslinked telopeptide of type I collagen] CTX-1, and those related to cartilage degradation [matrix metalloproteinase-1] MMP-1 and MMP-3, and lower baseline values of biomarkers related to inflammation, [hyaluronic acid] HA, leptin and adipsin, seem to be related to better response to chondroitin sulfate treatment in patients with knee OA,” the researchers wrote. “This is supportive of a potentially better response to treatment with chondroitin sulfate on cartilage volume loss in patients with knee OA with greater levels of cartilage catabolism and/or lower levels of inflammation.”

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Facebook Live broadcast of arthroscopic Bankart repair during podium presentation takes place at AOSSM Annual Meeting

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Original Research

Serum Creatine Kinase Levels in Division II National Collegiate Athletic Association Football Players During Preseason

Athletic Training and Sports Health Care
Online Advanced Release, July 5, 2017
To examine serum creatine kinase levels in Division II National Collegiate Athletic Association football players during…
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CME

Timing of Tourniquet Release in Total Knee Arthroplasty: July 2015

The authors conducted a meta-analysis to determine the optimal tourniquet application strategy in total knee…
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Resource Centers
American Orthopaedic Society for Sports Medicine Annual Meeting

American Orthopaedic Society for Sports Medicine Annual Meeting

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VIDEO Bariatric surgery linked to improvements in patients with knee OA

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