At 5 years after undergoing matrix-associated autologous chondrocyte implantation, researchers found patients’ outcomes were unaffected by whether the patients were assigned to accelerated or delayed weight-bearing activities.
From May 2004 to June 2007, the researchers prospectively compared 31 patients undergoing matrix-associated autologous chondrocyte implantation (MACI). Patients were randomly divided into an accelerated weight-bearing (AWB) group or a delayed weight-bearing (DWB) group.
Both groups underwent the same rehabilitation program, with the AWB group and DWB group given permission for full weight bearing after 6 weeks and 10 weeks, respectively. The rehabilitation program included weight-bearing replication training, range-of-motion restoration, muscle strength and neuromuscular exercises.
The researchers assessed the groups at 3 months, 2 years and 5 years after surgery. Magnetic resonance observation of cartilage tissue repair (MOCART), MRI-based variables bone edema and effusion, KOOS and Tegner scale scores were collected, and associations between MRI-based outcomes and KOOS were evaluated at 5 years postoperatively.
Results showed there was no infection, thrombosis, arthrofibrosis or graft delamination observed at the 5-year follow-up. MOCART scores had decreased and bone edema had increased significantly, but the difference between the groups was not significant, according to the researchers.
With the exception of bone edema and the KOOS subscale of pain, there were no correlations observed between MRI-based outcomes and any of the KOOS subscales. – by Monica Jaramillo
Disclosure: The researchers report no relevant financial disclosures.