Perioperative IV acetaminophen did not affect intraoperative or postoperative opioid use and pain score after minimally invasive spine surgeries, according to results presented at the Regional Anesthesiology and Acute Pain Medicine Meeting.
“While IV acetaminophen may benefit a carefully selected subset of patients undergoing surgery, more work needs to be done to determine which patients will have the greatest benefit,” researchers wrote in the abstract. “Due to the cost and difficulty obtaining IV acetaminophen in some institutions, our findings suggest that IV acetaminophen may not be necessary in the average patient undergoing minimally invasive spine surgery.”
Researchers performed a retrospective chart review of 187 patients who underwent minimally invasive discectomy decompression or laminectomy between 2014 and 2018 at either the Keck Medical Center or the Verdugo Hills Hospital. They divided medical charts into two groups which included patients who received IV acetaminophen and patients who did not. The two groups were compared with regard to the total dose of opioids administered during and after surgery. The initial, maximum and mean VAS pain scores were compared between the two groups. Patients who received IV acetaminophen in the first hour after surgical incision were compared with patients who received IV acetaminophen after the first hour of surgery.
Results showed patients who received IV acetaminophen compared with patients who did not were not significantly different with regard to the total intraoperative morphine-milligram equivalents. Investigators noted the total morphine-milligram equivalents at postoperative day 0 and postoperative day 1 were also not significantly different between patients who received IV acetaminophen and those who did not.
Groups were not different with regard to the initial, maximum or mean postoperative VAS pain scores. Outcome measures were not different within the group of patients who received IV acetaminophen in the first hour of surgery or after the first hour of surgery. – by Monica Jaramillo
Le Clair M, et al. Abstract 6751. Presented at: Regional Anesthesiology and Acute Pain Medicine Meeting; April 11-13, 2019; Las Vegas.
Disclosure: Le Clair reports no relevant financial disclosures.