In the Journals

Study finds contrast MRI findings predictive of tumor proliferation, motor status for spinal schwannoma

Investigators of this study found contrast T1-weighted MRI was predictive of tumor proliferation and spinal schwannomas growth, as well as correlated with larger tumor size and adhesion.

Researchers identified 48 patients who underwent tumor resection for spinal schwannoma. The mean duration of the disease was 17.5 months. Investigators classified the spinal schwannomas into the following three subgroups based on MRI findings using T2-weighted images and contrast T1-weighted images: isointense/homogenous; high/rim; or hetero/hetero. Tumor size and MIB-1 index were retrospectively analyzed with regard to the MRI findings. Preoperative and postoperative motor status were also assessed.

Results showed on average the tumor size was 32.4 mm and, on average, the MIB-1 index was 3.8%. Investigators noted the subgroups were not significantly different with regard to sex, age, disease duration, tumor lesion and dumbbell type. Compared with the other subgroups, the hetero/hetero group had a significantly higher MIB-1 index and significantly greater tumor size.

According to researchers, hetero tumors had significantly higher tumor adherence rates. In cases with tumor adhesion, preoperative paralysis was common. Cases with hetero tumors had significantly lower improvements in the paralysis rate at 1 month, but investigators found improvements seen in all cases at 6 months. by Monica Jaramillo

Disclosure : The researchers report no relevant financial disclosures.

Investigators of this study found contrast T1-weighted MRI was predictive of tumor proliferation and spinal schwannomas growth, as well as correlated with larger tumor size and adhesion.

Researchers identified 48 patients who underwent tumor resection for spinal schwannoma. The mean duration of the disease was 17.5 months. Investigators classified the spinal schwannomas into the following three subgroups based on MRI findings using T2-weighted images and contrast T1-weighted images: isointense/homogenous; high/rim; or hetero/hetero. Tumor size and MIB-1 index were retrospectively analyzed with regard to the MRI findings. Preoperative and postoperative motor status were also assessed.

Results showed on average the tumor size was 32.4 mm and, on average, the MIB-1 index was 3.8%. Investigators noted the subgroups were not significantly different with regard to sex, age, disease duration, tumor lesion and dumbbell type. Compared with the other subgroups, the hetero/hetero group had a significantly higher MIB-1 index and significantly greater tumor size.

According to researchers, hetero tumors had significantly higher tumor adherence rates. In cases with tumor adhesion, preoperative paralysis was common. Cases with hetero tumors had significantly lower improvements in the paralysis rate at 1 month, but investigators found improvements seen in all cases at 6 months. by Monica Jaramillo

Disclosure : The researchers report no relevant financial disclosures.