Injection of a soft tissue repair matrix combined with platelet-rich plasma may significantly improve clinical outcomes among patients with lateral epicondylitis, according to published results.
Researchers assessed grip strength, functional disability and changes in sonographic tendon appearance for up to 6 months in 40 patients with lateral epicondylitis who received a Vergenix Soft Tissue Repair Matrix (CollPlant Ltd.) injection combined with autologous PRP.
Results showed no systemic or local severe adverse events among patients. Researchers noted improved mean patient-rated tennis elbow evaluation scores, as well as a 59% reduction from baseline at 6 months. At final follow-up, the SF-12 questionnaire improved from a mean score of 30.7 to 37.7, according to results. Researchers found an increase in grip strength from 28.8 kg at baseline to 36.8 kg at 6 months, as well as improvements in sonographic tendon appearance among 68% of patients.
Despite predictions of a long-lasting effect of treatment that are limited by the relatively short follow-up period, the researchers noted other studies have reported only short-term pain relief with injection treatments for lateral epicondylitis.
“Furthermore, the short-term benefits, or possibly the accelerating effort, of injectable treatments in terms of disability, lost productivity and quality of life cannot be ruled out,” the authors wrote. – by Casey Tingle
Disclosures: The authors report no relevant financial disclosures.