Osteoporosis

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Long-term denosumab therapy safe, effective in postmenopausal osteoporosis

May 31, 2017

Postmenopausal women with osteoporosis assigned denosumab therapy for up to 10 years saw sustained gains in bone mineral density and reductions in bone turnover with low fracture incidence vs. women assigned to placebo, according to an analysis of the FREEDOM extension trial.

“The year-by-year results show that the safety profile of denosumab remained consistent and favorable over 10 years of treatment,” Henry G. Bone, MD, of the division of metabolism, endocrinology and diabetes at the University of Michigan in Ann Arbor, and colleagues wrote. “In this aging population, the participant incidence of adverse events — such as serious infection, cellulitis, eczema and malignancy — remained low. ... Thus, many of the questions that were initially raised about long-term safety with denosumab’s unique mechanism of action have largely been addressed.”

ARCH study: Romosozumab data show increased cardiovascular risk

May 22, 2017
Treatment with the anti-sclerostin monoclonal antibody romosozumab resulted in fewer new fractures in postmenopausal women with high-risk osteoporosis compared with…
In the Journals

ACP issues guidelines to reduce fracture risk in women with osteoporosis

May 8, 2017
Today, the ACP released an updated evidence-based clinical practice guideline strongly recommending that physicians treat women with osteoporosis with denosumab or…
In the Journals

Hormone therapy linked with decreased fracture risk for postmenopausal women

May 5, 2017
Among postmenopausal women, investigators found the risk of fracture decreased with the use of hormone therapy. Moreover, the findings were particularly true for women…
Feature Article

Impact of Passive Smoking on the Bones of Rats

Orthopedics, February/March 2010, Volume 33 Issue 2
Many epidemiological surveys have identified smoking as a risk factor for osteoporosis, but it is unclear whether…
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CME

Effect of Topical Tranexamic Acid in Reducing Bleeding and Transfusions in TKA: May 2015

Intravenous tranexamic acid (TXA) has been identified to be effective in total knee arthroplasty (TKA), but the effect…
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VIDEO: Decades of research point to therapies to discourage bone aging

September 20, 2016
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In the Journals Plus

Long-term denosumab therapy safe, effective in postmenopausal osteoporosis

May 31, 2017
Postmenopausal women with osteoporosis assigned denosumab therapy for up to 10 years saw sustained gains in bone mineral density and reductions in…

ARCH study: Romosozumab data show increased cardiovascular risk

May 22, 2017
Treatment with the anti-sclerostin monoclonal antibody romosozumab resulted in fewer new fractures in postmenopausal women with high-risk…

In the Journals

ACP issues guidelines to reduce fracture risk in women with osteoporosis

May 8, 2017
Today, the ACP released an updated evidence-based clinical practice guideline strongly recommending that physicians treat women with osteoporosis…

In the Journals

Hormone therapy linked with decreased fracture risk for postmenopausal women

May 5, 2017
Among postmenopausal women, investigators found the risk of fracture decreased with the use of hormone therapy. Moreover, the findings were…

FDA News

FDA approves Tymlos for postmenopausal women with osteoporosis

April 28, 2017
The FDA today approved an abaloparatide injection for the treatment of postmenopausal women with osteoporosis at high risk for fracture, according to…

In the Journals

Benefits, harms of osteoporosis medications in chronic kidney disease uncertain

April 11, 2017
There are no clearly established effects of osteoporosis medications on bone mineral density, fracture risk and safety in patients with chronic…

CDC reports FRAX-based 10-year probability of hip, major osteoporotic fractures in middle-aged adults

April 6, 2017
The National Center for Health Statistics of the CDC recently published data that offered a FRAX-based estimation of the 10-year probability of…

In the Journals

Denosumab found safe in long-term extension trial

March 23, 2017
Denosumab in the treatment of patients with osteoporosis did not show any increase in common adverse events in a long-term trial, according to…

In the Journals

Researchers identify possible early warning signs for osteoporosis in South Asian women

March 22, 2017
In premenopausal South Asian women, researchers identified higher levels of urinary N-telopeptide — a by-product for bone resorption —…

Meeting News

Men had greater risk for death after osteoporosis-related fracture compared with women

March 21, 2017
SAN DIEGO — Compared with women, men had a greater risk for death after an osteoporosis-related fracture, according to a press release and…

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