Geoffrey H. Westrich
LAS VEGAS — Results presented at the American Academy of Orthopaedic Surgeons showed no differences in pain scores or opioid consumption with the use of IV acetaminophen compared with oral acetaminophen as postoperative analgesia after total hip arthroplasty.
Geoffrey H. Westrich, MD, and colleagues randomly assigned 154 patients undergoing THA to receive either oral acetaminophen with an IV placebo or IV acetaminophen with oral placebo postoperatively. The primary outcome included pain with physical therapy on postoperative day 1, opioid-related symptom distress scale score on postoperative day 1 and cumulative opioid use during the first 3 postoperative days converted to oral morphine equivalents.
“If we look at the two groups between IV and oral and we compare them, you can see that there were no differences in any of the factors between the two groups when evaluated by our statisticians,” Westrich said in his presentation.
Westrich also noted no differences between the two groups for any of the primary outcome measures. Over time, the groups had similar pain scores, according to Westrich.
“If we look at our secondary outcomes, even though we evaluated numerous outcomes, we did not see any that had a statistically significant difference,” he said. “I will point out that if you look at the patient satisfaction, both groups had extremely high patient satisfaction with this low-opioid protocol.” – by Casey Tingle
Westrich GH, et al. Abstract 136. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 12-15, 2019; Las Vegas.
Disclosure: Westrich reports he receives IP royalties from Exactech Inc. and Stryker; is a paid consultant for Exactech Inc. and Stryker; is a paid presenter or speaker for Exactech Inc., Mallinckrodt Pharmaceuticals and Stryker; and receives research support from Exactech Inc., Mallinckrodt Pharmaceuticals and Stryker.