Orthopedics

Review Article Free

Osteonecrosis of the Femoral Head

George C Babis, MD, PhD; Vasileios Sakellariou, MD, MSc; Javad Parvizi, MD; Panayiotis Soucacos, MD, PhD

Osteonecrosis, also known as avascular necrosis or ischemic necrosis of the femoral head, is a pathologic process that results from interruption of blood supply to the bone. The accurate prevalence of disease is unknown, but 10,000 to 20,000 new cases are diagnosed in the United States per year.1,2 An estimated 5% to 18% of the more than 500,000 total hip arthroplasties (THAs) performed annually are for osteonecrosis of the femoral head.1,2

The etiology of osteonecrosis is believed to be multifactorial and associated in some cases with both a genetic predilection and exposure to certain risk factors (Table 1).3-6

Trauma is a potential cause due to disruption of the blood supply from the superior retinacular vessels and the nutrient artery as well as the increases of intracapsular pressure due to intracapsular hematoma following a femoral neck fracture. In cases of hip dislocation the artery of the ligamentum teres is damaged. Extracapsular lesions, as intertrochanteric fractures, rarely result in avascular necrosis.3-6

Table 1: Etiological Factors

The use of corticosteroids7-9 is the most common risk factor accounting for almost 10% to 30% of osteonecrosis cases. However, only 8% to 10% of patients exposed to corticosteroid therapy may develop osteonecrosis.9 Dosages typically considered to be associated with the disease are >2 g of prednisone, or its equivalent, within a 2- to 3-month period.8 Koo et al9 found that the total dose of corticosteroids used until osteonecrosis was detected with magnetic resonance imaging (MRI) ranged from 1800 to 15500 mg (mean, 5928 mg) of prednisolone or its equivalent.

The period from the start of corticosteroid treatment to the diagnosis of osteonecrosis ranges from 1 to 16 months (mean, 5.3 months), and the majority of patients are diagnosed within 12 months.9 In an animal model, Korompilias et al10 reported that corticosteroids may act as a trigger, potentiating the effects of a pre-existing condition and increasing the risk of osteonecrosis. These authors also found evidence supporting that the immunologic reaction was important in the pathogenesis of the disease.

Excessive alcohol intake has been identified as an etiologic factor in osteonecrosis. The relative risk increases from 2.7 for <4000 drink-years (with drink-years defined as weekly alcohol consumption multiplied by the number of years of drinking) to 9.0 for 10,000 drink-years.11 One prospective study12 suggested that an intake of >400 mL of alcohol per week increased the relative risk of osteonecrosis 9.8-fold. Occasional drinkers (<8 mL of alcohol once a week, but not daily) (relative odds=3.2) and regular drinkers (8 mL of alcohol daily) (relative odds=13.1) are found to have a higher risk to develop osteonecrosis than controls. A significant dose-response relationship (P<.001) was found, with the relative odds for current drinkers being 2.8, 9.4, and 14.8 in association with ethanol intakes of <320, 320 to 799, and 800 g/wk, respectively.

Smoking has been implicated as a risk factor for osteonecrosis of the femoral head.12-14 Hirota et al13 showed that there is an increased risk for current smokers (relative odds=4.7); however, a cumulative effect of smoking was evident only in association with >20 pack-years. Matsuo et al12 also found an increased risk for current smokers (relative risk=3.9). Various studies have demonstrated that smoking inhibits osteogenesis or fracture healing.14-16

Osteonecrosis has been associated with several hemoglobinopathies including hemoglobin SS (sickle cell disease), hemoglobin SC, and sickle thalassemia. The reported prevalence of osteonecrosis in these populations has been 4% to 20%.11,17,18 Studies have shown an association with thrombophilia and hypofibrinolysis.11,17 At least 1 coagulation factor abnormality was found in 82% of patients with osteonecrosis of the femoral head compared with 30% of controls (P<.0001).11 Two or more abnormalities were identified in 21 patients (47%) compared with 2.5% of controls (P<.0001). Glueck et al17 found a high prevalence of plasminogen activator inhibitor-1 coagulation abnormalities in patients with osteonecrosis. The same author showed that heritable hypofibrinolysis and thrombophilia, often augmented in women by hyperestrogenemia, are major pathoetiologies of osteonecrosis, and proposed anticoagulation therapy with Enoxaparin.18

Patients infected with human immunodeficiency virus (HIV) are also at increased risk.19,20 It is unclear whether the virus or the medications used are the pathogenic agents. Several studies have implicated antiretroviral therapy as the most important pathogenic agent.19,20 Ries et al21 found 4 patients with HIV and osteonecrosis of the femoral head that were not treated with retroviral drugs, a finding that suggests that HIV infection may be a unique risk factor.

A recent study22 demonstrated a potential for autosomal dominant inheritance, for osteonecrosis of the femoral head, mapping the chromosomal position of a collagen type-II gene (COL2A1 gene) mutation. It has also been associated with certain genetic polymorphisms such as alcohol-metabolizing enzymes and the drug-transport protein P-glycoprotein.23-25 Glueck et al26 recently found that eNOS polymorphisms may be associated with a risk of development of idiopathic osteonecrosis. The T-786C eNOS mutation was associated with idiopathic osteonecrosis but was not associated with secondary osteonecrosis (P=.52, P=.19). Moreover, in the current study, the smoking-eNOS genotype interaction was associated with idiopathic osteonecrosis (P<.0001). The importance of their findings is that genetic screening of families with osteonecrosis of the femoral head could be used to identify carriers before the onset of clinical symptoms, allowing for initiation of measures that could delay disease progression.

The pathogenesis of osteonecrosis was recently reviewed and a unifying theory that focuses on the role of ischemia was presented.27 Ischemia can be produced by vascular interruption (fractures or dislocations), by thrombotic occlusion (intravascular coagulation), or by extravascular compression (marrow fat enlargement).27

Current evidence suggests that intravascular coagulation and microcirculatory thrombotic occlusion likely provide a final common pathway for nontraumatic osteonecrosis. Arteriolar and other intravascular thromboses have been found in large numbers of osteonecrotic femoral heads.28 Microcirculatory thrombosis associated with fat emboli has been described. Elevated levels of fibrinopeptides and fibrin degradation products have been measured in some cases of osteonecrosis providing indirect evidence of ongoing thrombosis.28

Several studies have demonstrated the presence of hypofibrinolysis and thrombophilia in patients with osteonecrosis.18,29 Hypofibrinolysis is usually associated with a low level of tissue plasminogen activator, elevated levels of plasminogen activator inhibitor, and high levels of lipoprotein A. Thrombophilia is characterized by decreased levels of the antithrombotic proteins C or S, and resistance to activated protein C. Both hypofibrinolysis and thrombophilia are accompanied by an increased incidence of clinical thrombotic events contributing to the pathogenesis of osteonecrosis. However, other studies have suggested that these coagulopathies may not be specific for osteonecrosis and are present in other diseases including osteoarthritis,30 and bone marrow edema syndrome.31

Corticosteroid administration has been associated with osteonecrosis as a sequence of fat cell proliferation and hypertrophy. It produces a significant amount of fat accumulation in marrow due to both adipocyte hypertrophy and hyperplasia, which results in intraosseous hypertension and diminished blood flow.7

Classification & Staging

It is generally agreed that successful treatment of patients with osteonecrosis is related directly to the stage of disease at diagnosis, which stresses the importance of a reliable classification system.32-34 A number of different classification systems, presented in Table 2, have been developed to evaluate patients with osteonecrosis, but there is no standard unified classification system for determining the extent and location of the necrotic area in the femoral head.

Table 2: Classification Systems
Table 2: Click the table to view it in a larger format.

The study by Plakseychuk et al,38 which was designed to assess the reliability of a commonly used classification systems, showed an unacceptably high intraobserver and interobserver error rate. In light of the need for an accurate standard classification system, the authors proposed a 3-stage Pittsburgh classification system based on MRI, structure of the femoral head, and contour of the femoral head as seen on plain radiographs (Table 2).

Each staging system has limitations, and no single system has been universally accepted for use alone as a guide to treatment. The different classification systems could be equally applicable based on the comparison of different studies according to Mont et al.39 These authors found several similarities and concluded that if specific MRI and radiographic data are collected, comparison of studies using different systems of classification could be allowed.

Four essential radiographic findings have been routinely used by most authors when formulating a treatment plan. These findings, which have been corroborated in peer-reviewed studies of outcomes of various treatment methods, include (1) evidence that the lesion is either precollapse or postcollapse, (2) the size of the necrotic segment, (3) the amount of femoral head depression, and (4) acetabular involvement with signs of osteoarthritis.

Steinberg et al34 described a method for assessing the amount of femoral head involvement by these lesions with MRI. Volumetric measurements are calculated from coronal and axial images. Lesions that occupy <15% of the femoral head are defined as mild, 15% to 30% as moderate or medium, and >30% of the femoral head as severe lesions. Cherian et al40 showed that various methods for measuring the sizes of lesions (calculation of an index of necrotic extent and estimation of the percent involvement) could be used with confidence as they were highly reliable and reproducible.

The importance of the extent of the lesion and its exact localization is highlighted by Theodorou et al41 who related it to successful treatment. Because the ideal location for the fibular graft depends on the size, location, and configuration of an individual lesion, patient-specific modeling with computerized optimization offers the potential to enhance structural contributions to the healing process. The authors observed a wide range of lesion sizes for each stage, and progression according to lesion size frequently was observed without an increase in the stage of the disease, according to one of the major classification systems. Moreover, although the lesion size varied between MRI and radiographs, measurements of the necrotic area on radiographs correlated with measures on MRI according to the level of the MR slice, with lesion sizes measured on radiographs proportionate to MRI taken posterior to the midcoronal plane of the femoral head.

Arthroscopic evaluation has been also used.42-44 Sekiya et al44 reported on the difficulties that surround decision making in “middle grade” osteonecrosis of the hip. By showing poor correlation between plain radiography, MRI, and hip arthroscopy, the authors made a convincing argument for direct inspection of the femoral head when MRI shows stage IV disease. Patients in the MRI stage IV subgroup were found at arthroscopy to have articular surfaces that were variously salvageable or severely delaminated (ie, stages III to V).

Magnetic resonance imaging has been shown to be inadequate at assessing the articular cartilage. Therefore, either arthroscopy or direct visualization is required for accurate evaluation and staging, especially in stage IV disease. In another study, Ruch et al43 used arthroscopy to study 52 hips with osteonecrosis in 18 hips in which loss of integrity of the femoral head had been noted on plain radiographs, arthroscopy of the hip revealed osteochondral degeneration not detected by MRI. McCarthy et al42 used arthroscopy to study 7 patients and concluded that this procedure could enhance the accuracy of staging.

Treatment Options

Nonoperative Treatment

Nonoperative treatment usually results in a poor prognosis. Most methods of nonoperative treatment have involved restricted weight bearing, pharmacologic agents, and various external, biophysical, nonoperative modalities (Table 3).

Table 3: Treatment Options

Restricted weight bearing (with various modalities such as canes, crutches, or walkers) is believed to slow the progression of the disease. The rates for preservation of the femoral head as reported by Mont and Hungerford45 are 35% for stage 1 hips, 31% for stage 2 hips, and 13% for stage 3 hips. Femoral head collapse is seen in >85% of cases. However, protected weight bearing may be effective for small lesions located within the medial portion of the femoral head.38

The use of pharmacological agents has received considerable attention in recent years. Pritchett46 reported that at a mean of 7.5 years osteonecrosis of the femoral head had been developed in only 1% of patients who were taking high doses of corticosteroids as well as various statin drugs (lipid-clearing agents that dramatically reduce lipid levels). That prevalence is much lower than the 3% to 20% prevalence reported for patients receiving high-dose corticosteroids without statins.4,47

Glueck et al48 used the anabolic steroid stanozolol (6 mg/day) to treat 4 patients who had hypofibrinolysis associated with a high level of plasminogen activator activity and 1 patient who had a high level of lipoprotein in the serum. In another study49 enoxaparin, a low-molecular-weight heparin (60 mg/day for 12 weeks), was used to treat patients who had thrombophilic or hypofibrinolytic disorders and early stages of osteonecrosis with a 89% success rate.

Iloprost, a prostacyclin derivative used as a vasodilator, has been studied in patients with osteonecrosis and bone marrow edema50,51 promising clinical and radiographic improvements at 1 year of treatment.

Use of bisphosphonates is associated with reduction in the prevalence of femoral head collapse.52,53 Recent clinical reports have suggested that alendronate can be potentially beneficial in patients with nontraumatic osteonecrosis52,53 and IV biphosphonates in adolescents with traumatic femoral osteonecrosis.

Zaidi et al54 reported lately that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). The authors attributed this therapeutic outcome to enhanced osteoblastic support and stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone.

Electromagnetic stimulation, extracorporeal shock-wave therapy55 and hyperbaric oxygen56,57 have also been used with controversial results.

Operative Treatment

Core decompression. Core decompression is currently the most common procedure in the early stages of osteonecrosis of the femoral head.58 The goal is to decompress the femoral head and thereby reduce the intraosseous pressure in the femoral head, restore normal vascular flow, and subsequently reduce the hip pain.58

We are aware of only a few randomized trials in which the efficacy of core decompression alone was assessed, as it is usually combined with other treatment options. Stulberg et al59 compared core decompression alone with conservative treatment in a prospective, randomized study of 55 hips. Based on Harris hip scores, operative treatment was successful in approximately 70% of hips with Ficat Stage-I, II, or III osteonecrosis comparing to 20% of nonoperative management of early osteonecrosis.

Core decompression is usually combined with nonvascularized grafts (allograft bone or demineralized bone matrix),60 vascularized bone grafts (fibula or iliac crest),61,62 electrical stimulation,63 or electromagnetic fields.64

There is also interest in using growth factors that can enhance osteogenesis (bone morphogenetic protein) or angiogenesis (fibroblast growth factor or vascular endothelial growth factor). In a recent study, Cui et al65 demonstrated that cloned bone marrow stem cells can directly form bone after transplantation into bone defects and at ectopic sites, indicating that the in vitro expanded bone marrow stem cells can serve as a graft material to enhance bone repair and to treat osteonecrosis.

Early results from the treatment of osteonecrotic lesions with autologous bone graft that included bone marrow cells, with or without growth factors, have shown favorable outcomes.65-68 Hernigou and Beaujean69 had a 94% success rate (avoidance of THA) on hips that had been operated before collapse. Clonal stem-cell lines can be pivotal tools to define the characteristics of marrow stem cells in fracture-healing and bone repair, but information on this topic is limited. With use of gene-labeling techniques, Cui et al65 demonstrated that the cloned bone-marrow stem cell can directly form bone after transplantation into bone defects or into ectopic sites, indicating that the in vitro expanded bone marrow stem cells can serve as a grafting material to enhance healing of femoral defects.

Lieberman et al66 reported on the use of bone morphogenetic proteins for the treatment of osteonecrosis of the femoral head with clinically successful result in 14 out of 17 hips and no patient requiring conversion to a THA. Some investigators have reported good results in patients with a collapsed femoral head, but only small numbers of patients have been studied.70,71

Free vascularized fibular grafts. The use of vascularized bone grafts to treat osteonecrosis of the femoral head was developed to prevent collapse of the femoral head and to enhance vascularization of the bone in this region.72 The use of free vascularized fibular grafts is a reasonable option for patients younger than 50 years without collapse of the femoral head. The procedure is more controversial in patients with collapse of the femoral head, and whether it is used should be determined by the diagnosis, patient age, and the extent of disease progression. However, a vascularized fibular graft may be considered as a treatment option to avoid performing arthroplasty in patients younger than 20 years with 2 or 3 mm of collapse and acetabular involvement.62

The Ioannina technique73 uses serial computed tomography (CT) scans of the proximal femur to identify the configuration of the femur, and the size, location, and configuration of the lesion. Optimal graft placement is determined and translated into a patient-specific aiming device with a predrilled guide wire canal. The authors report that the arbitrary placement of the graft during conventional fibular graft surgery leads to accurate graft placement in only 55% of the patients, whereas the use of the patient-specific Ioannina Aiming Device resulted in optimal graft placement in 89% of the patients.

Successful results with free vascularized fibular graft technique have been reported at a number of centers.62,72 The expected 10-year survivorship ranges from 74% to 82%. Patients with preoperative collapse of the femoral head had a worse prognosis. Conversion to THA was needed in 13% to 28% of patients.62,72,74

Nonvascularized bone grafts. Nonvascularized bone grafts have numerous theoretical advantages for the treatment of pre-collapse and early post-collapse osteonecrosis of the femoral head when the articular cartilage is relatively undamaged.75 No consensus exists regarding the indications for nonvascularized bone grafting. Most authors recommend them for hips with <2 mm of femoral head depression or those in which a core decompression has failed and there is no acetabular involvement. Some investigators have reported good results in patients with a collapsed femoral head, but only small numbers of patients have been studied.71,75 However, the indications for nonvascularized bone grafting may increase in the future as the primary results from addition of growth factors and various bone-graft substitutes are promising.71,75

Cortical strut-grafting has shown a wide range of success rates. Boettcher et al76 reported clinical and radiographic success in 71% of hips after 6 years of follow-up. However, in a long-term evaluation by Smith et al77 that included the original 38 patients evaluated by Boettcher et al, 40 (71%) of 56 hips had a poor clinical result at a mean follow-up of 14 years (range, 4-27 years).76 However, Dunn and Grow78 reported only 4 good results in 23 patients so treated. Buckley et al79 reported excellent clinical result at a mean follow-up of 8 years (range, 2-19 years) in 18 (90%) of 20 hips that had Ficat Stage I or II disease.

Osteotomies. Osteotomies are used to move the segment of necrotic bone away from the weight-bearing region. A report on 474 patients treated with rotational osteotomy revealed a success rate of 78%, with higher success rates seen in cases in earlier stages (stage II had an 89% success rate, stage III 73%, and stage IV 70%), and in cases involving smaller lesions. In those involving less than one third of the articular surface procedures were successful in 93% of cases compared with only 64% success in those involving more than one third. The outcome was also related to the ratio of the transposed posterior articular surface to the weight-bearing area of the acetabulum.80

Inao et al,81 in a 10-year follow-up study of 14 rotational osteotomies, noted excellent results with minimal degenerative changes after 15 years in all patients with <2 mm of collapse and no acetabular changes. Overall, success rate was 78%.

The results of angular osteotomies82,83 are variable, with success rates ranging from 40% to 96% at 3- to 26-years postoperatively. The angular osteotomies offered better results in young active patients who were not taking corticosteroids, had unilateral involvement with a good preoperative range of hip motion, and had a small lesion without femoral head collapse.

Canadell et al84 supported the relevance of lesion size in a series of 102 intertrochanteric osteotomies. At an average follow-up of 4.2 years, the best results were in patients with necrotic angles <200° (69% satisfactory outcome) compared with those with more extensive involvement (48% unsatisfactory). Poorer results were found in cases with more advanced lesions, with satisfactory results seen in 91% of cases in stage II, 56% in stage III, and 32% in stage IV.84

Tantalum rod. Porous tantalum is a biomaterial with a unique set of physical and mechanical properties. It has a high porosity (>80% of volume) with fully interconnected pores to allow secure and rapid bone ingrowth.85 The addition of bone marrow, growth factors, or bisphosphonates can augment bone formation around and within porous tantalum.86 Recently, Tsao et al87 reported favorable early clinical results indicating similar or better survival rates (92% at 48 months) than hips treated with core decompression and vascularized fibular grafting. Tanzer et al88 presented the results of a retrieval analysis of 15 clinically failed porous tantalum implants that were associated with little bone ingrowth and insufficient mechanical support of subchondral bone. Factors including the surgical technique, its application, and the clinical characteristics of candidates for this procedure should continue to be monitored closely.

Total joint replacement. Total hip arthroplasty is a predictably effective treatment of avascular necrosis of the femoral head when the disease is progressed to Ficat and Arlet’s32 stages III and IV. The underlying diagnosis associated with osteonecrosis of the femoral head appears to have an impact on implant durability. Use of corticosteroids, ethanol abuse, systemic lupus erythematosus, or organ transplants negatively affect the prosthetic durability.89

Cemented and cementless THAs have shown variable success rates related to demographic features of the patients in each cohort. Despite the difficulty of comparing different series, several generalizations can be made. Cemented components have shown increased loosening rates whereas cementless components have been associated with polyethylene wear and periprosthetic osteolysis.90

Development of modified polyethylene and alternative articulating surfaces (ceramic-on-polyethylene, ceramic-on-ceramic, and metal-on-metal) diminish or eliminate the generation of polyethylene particles, however, ceramic and metal particles are produced. Additional investigation is needed to identify the potential beneficial or harmful effects of these alternative-bearing surfaces.91

Limited femoral resurfacing arthroplasty. Patients with Ficat and Arlet Stage-III disease, a combined necrotic angle of >200° or >30% involvement, femoral head collapse of >2 mm, and no evidence of damage to the acetabular cartilage are the main candidates for limited femoral resurfacing arthroplasty.

Generally, limited femoral resurfacing arthroplasty has shown satisfactory results for up to 10 years.92-94 Recently, a few studies showed less predictable outcomes of these procedures with overall hip survivorship reaching 75.9% at 3 years.95 In a study of 59 hips followed for a mean of 4.5 years, Cuckler et al93 reported 18 failures.

Bipolar hemiarthroplasty. Variable success rates in the treatment of osteonecrosis of the femoral head have been reported.96,97 Femoral loosening, acetabular protrusio, osteolysis, and polyethylene wear98,99 are the main reported drawbacks of this reconstructive option, showing high complication rates98 and radiographic failure rates that reach 42%.99

Treatment Algorithm/Patient-specific Factors

Several considerations should be given when planning treatment of patients with osteonecrosis of the femoral head. Patient age, activity level, general health, comorbidities, and life expectancy are major contributing factors guiding the decision-making process. Treatment options will also be influenced by the surgeon’s familiarity with various procedures. Different treatment modalities offer better clinical outcome for each stage of disease.

Physical examination assessing the amount of pain, limp, and limitation of hip motion may also be used to determine the severity of joint involvement. Systemic disease or a short life expectancy may preclude a major surgical procedure. Patients with a severe medical background may be more appropriately treated with one definitive procedure (THA) rather than with procedures that may be only temporizing.

The duration of symptoms has been found to influence the outcomes of preservative treatment. In a previous study of 45 Ficat and Arlet Stage I and II hips in which core decompression was done by drilling multiple times with a percutaneous small diameter pin, a mean preoperative duration of symptoms of 6 months for patients who had a successful outcome compared with 11 months for those who had a poor outcome was reported.100 Beaulé et al101 observed a better prognosis for patients who had experienced symptoms for <12 months before treatment with limited femoral head resurfacing than for patients who had had symptoms for >12 months before such treatment.

Generally, nonoperative pharmacologic or biophysical treatment modalities should be preferred in asymptomatic hips with precollapse lesions. For later stage lesions, without distraction of the articular cartilage, osteotomies as well as bone grafting procedures, vascularized and nonvascularized, could be considered supplemented by bone marrow stem cells that can serve as a grafting material to enhance healing of femoral defects. An alternative option for this stage could be the use of tantalum rod. In situations where there is a limited defect of the femoral head cartilage without acetabular involvement, limited femoral head resurfacing could be considered. Finally, when acetabular involvement occurs, the only viable option is THA. Ceramic-on-polyethylene, ceramic-on-ceramic, and metal-on-metal bearings should be considered for active young patients.

References

  1. Lavernia CJ, Sierra RJ, Grieco FR. Osteonecrosis of the femoral head. J Am Acad Orthop Surg. 1999; 7(4):250-261.
  2. Vail TP, Covington DB. The incidence of osteonecrosis. In: Urbaniak JR, Jones JR, eds. Osteonecrosis: Etiology, Diagnosis, Treatment. Rosemont, IL: American Academy of Orthopedic Surgeons; 1997:43-49.
  3. Aldridge JM III, Urbaniak JR. Avascular necrosis of the femoral head: etiology, pathophysiology, classification, and current treatment guidelines. Am J Orthop. 2004; 33(7):327-332.
  4. Etienne G, Mont MA, Ragland PS. The diagnosis and treatment of nontraumatic osteonecrosis of the femoral head. Instr Course Lect. 2004; 53:67-85.
  5. Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect. 2003; 52:337-355.
  6. Inoue S, Horii M, Asano T, et al. Risk factors for nontraumatic osteonecrosis of the femoral head after renal transplantation. J Orthop Sci. 2003; 8(6):751-756.
  7. Wang GJ, Cui Q, Balian G. The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Clin Orthop Relat Res. 2000; (370):295-310.
  8. Griffith JF, Antonio GE, Kumta SM, et al. Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids [published online ahead of print February 9, 2005]. Radiology. 2005; 235(1):168-175.
  9. Koo KH, Kim R, Kim YS, et al. Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheumatol. 2002; 21(4):299-303.
  10. Korompilias AV, Gilkeson GS, Seaber AV, Urbaniak JR. Hemorrhage and thrombus formation in early experimental osteonecrosis. Clin Orthop Relat Res. 2001; (386):11-18.
  11. Jones LC, Hungerford DS. Osteonecrosis: etiology, diagnosis, and treatment. Curr Opin Rheumatol. 2004; 16(4):443-449.
  12. Matsuo K, Hirohata T, Sugioka Y, Ikeda M, Fukuda A. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res. 1988; (234):115-123.
  13. Hirota Y, Hirohata T, Fukuda K, et al. Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am J Epidemiol. 1993; 137(5):530-538.
  14. Gullihorn L, Karpman R, Lippiello L. Differential effects of nicotine and smoke condensate on bone cell metabolic activity. J Orthop Trauma. 2005; 19(1):17-22.
  15. Glassman SD, Anagnost SC, Parker A, Burke D, Johnson JR, Dimar JR. The effect of cigarette smoking and smoking cessation on spinal fusion. Spine (Phila Pa 1976). 2000; 25(20):2608-2615.
  16. Theiss SM, Boden SD, Hair G, Titus L, Morone MA, Ugbo J. The effect of nicotine on gene expression during spine fusion. Spine (Phila Pa 1976). 2000; 25(20):2588-2594.
  17. Glueck CJ, Fontaine RN, Gruppo R, et al. The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin Orthop Relat Res. 1999; (366):133-146.
  18. Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P. Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res. 2001; (386):19-33.
  19. Allison GT, Bostrom MP, Glesby MJ. Osteonecrosis in HIV disease: epidemiology, etiologies, and clinical management. AIDS. 2003; 17(1):1-9.
  20. Hasse B, Ledergerber B, Egger M, et al; Swiss HIV Cohort Study. Antiretroviral treatment and osteonecrosis in patients of the Swiss HIV Cohort Study: a nested case-control study. AIDS Res Hum Retroviruses. 2004; 20(9):909-915.
  21. Ries MD, Barcohana B, Davidson A, Jergesen HE, Paiement GD. Association between human immunodeficiency virus and osteonecrosis of the femoral head. J Arthroplasty. 2002; 17(2):135-139.
  22. Liu YF, Chen WM, Lin YF, et al. Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Engl J Med. 2005; 352(22):2294-2301.
  23. Asano T, Takahashi KA, Fujioka M, et al. Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects. Transplantation. 2004; 77(2):220-225.
  24. Baldwin C, Nolan VG, Wyszynski DF, et al. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis [published online ahead of print March 22, 2005]. Blood. 2005; 106(1):372-375.
  25. Zalavras CG, Malizos KN, Dokou E, Vartholomatos G. The 677C-->T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head. Haematologica. 2002; 87(1):111-112.
  26. Glueck CJ, Freiberg RA, Oghene J, Fontaine RN, Wang P. Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur. J Bone Joint Surg Am. 2007; 89(11):2460-2468.
  27. Aaron RK. Osteonecrosis: etiology, pathophysiology, and diagnosis. In: Callaghan J, Rosenberg A, Rubash H, eds. The Adult Hip. New York, NY: Raven Press; 1998:451-466.
  28. Saito S, Ohzono K, Ono K. Early arteriopathy and postulated pathogenesis of osteonecrosis of the femoral head. Clin Orthop Relat Res. 1992; (277):98-110.
  29. Glueck CJ, Glueck HI, Welch M, et al. Familial idiopathic osteonecrosis mediated by familial hypofibrinolysis with high levels of plasminogen activator inhibitor. Thromb Haemost. 1994; 71(2):195-198.
  30. Cheras PA, Whitaker AN, Blackwell EA. Hypercoagulability and hypofibrinolysis in primary osteoarthritis. Clin Orthop Relat Res. 1997; 334:57-67.
  31. Berger CE, Kluger R, Urban M. Elevated levels of lipoprotein(a) in familial bone marrow edema syndrome of the hip. Clin Orthop Relat Res. 2000; (377):126-131.
  32. Ficat RP, Arlet J. Functional investigation of bone under normal conditions. In: Ficat RP, Arlet J, Hungerford DS, eds. Ischemia and Necrosis of Bone. Baltimore, MD: Williams and Wilkins; 1980:29-52.
  33. ARCO (Association Research Circulation Osseous)- Committee on Terminology and Staging: The ARCO Perspective for Reaching One Uniform Staging System of osteonecrosis. In: Schoutens A, Arlet J, Gardeniers J, et al, eds. Bone Circulation and Vascularization in Normal and Pathological Conditions. New York, NY: Plenum Press; 1993:375-380.
  34. Steinberg M, Hayken G, Steinberg D. A quantitative system for staging avascular necrosis. J Bone Joint Surg Br. 1995; 77(1):34-41.
  35. Ficat RP, Arlet J. Necrosis of the femoral head. In: Hungerford DS, ed. Ischemia and Necrosis of Bone. Baltimore, MD; Williams and Wilkins; 1980:171.
  36. Marcus ND, Enneking WF, Massam RA. The silent hip in idiopathic aseptic necrosis. Treatment by bone-grafting. J Bone Joint Surg Am. 1973; 55(7):1351-1366.
  37. Ono K. Diagnostic criteria, staging system and roentgenographic classification of avascular necrosis of the femoral head (steroid induced, alcohol associated or idiopathic nature) [in Japanese]. In: Ono K, ed. Annual Report of Japanese Investigation Committee for Intractable Disease, Avascular Necrosis of the Femoral Head. Vol 331. Tokyo: Ministry of Health and Welfare; 1987:331-336.
  38. Plakseychuk AY, Shah M, Varitimidis SE, Rubash HE, Sotereanos D. Classification of osteonecrosis of the femoral head reliability, reproducibility, and prognostic value. Clin Orthop Relat Res. 2001; (386):34-41.
  39. Mont MA, Marulanda GA, Jones LC, et al. Systemic analysis of classification systems for osteonecrosis of the femoral head. J Bone Joint Surg Am. 2006; 88(supplement 3):16-26.
  40. Cherian SF, Laorr A, Saleh KJ, Kuskowski MA, Bailey RF, Cheng EY. Quantifying the extent of femoral head involvement in osteonecrosis. J Bone Joint Surg Am. 2003; 85(2):309-315.
  41. Theodorou DJ, Malizos KN, Beris AE, Theodorou SJ, Soucacos PN. Multimodal imaging quantitation of the lesion size in osteonecrosis of the femoral head. Clin Orthop Relat Res. 2001; (386):54-63.
  42. McCarthy J, Puri L, Barsoum W, Lee JA, Laker M, Cooke P. Articular cartilage changes in avascular necrosis: an arthroscopic evaluation. Clin Orthop Relat Res. 2003; (406):64-70.
  43. Ruch DS, Sekiya J, Dickson Schaefer W, Koman LA, Pope TL, Poehling GG. The role of hip arthroscopy in the evaluation of avascular necrosis. Orthopedics. 2001; 24(4):339-343.
  44. Sekiya JK, Ruch DS, Hunter DM, et al. Hip arthroscopy in staging avascular necrosis of the femoral head. J South Orthop Assoc. 2000; 9(4):254-261.
  45. Mont MA, Hungerford DS. Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am. 1995; 77(3):459-474.
  46. Pritchett JW. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin Orthop Relat Res. 2001; (386):173-178.
  47. Chernetsky SG, Mont MA, LaPorte DM, Jones LC, Hungerford DS, McCarthy EF. Pathologic features in steroid and nonsteroid associated osteonecrosis. Clin Orthop Relat Res. 1999; (368):149-161.
  48. Glueck CJ, Freiberg R, Glueck HI, Tracy T, Stroop D, Wang Y. Idiopathic osteonecrosis, hypofibrinolysis, high plasminogen activator inhibitor, high lipoprotein(a), and therapy with Stanozolol. Am J Hematol. 1995; 48(4):213-220.
  49. Glueck CJ, Freiberg RA, Sieve L, Wang P. Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin Orthop Relat Res. 2005; (435):164-170.
  50. Disch AC, Matziolis G, Perka C. The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J Bone Joint Surg Br. 2005; 87(4):560-564.
  51. Meizer R, Radda C, Stolz G, et al. MRI-controlled analysis of 104 patients with painful bone marrow edema in different joint localizations treated with the prostacyclin analogue iloprost. Wien Klin Wochenschr. 2005; 117(7-8):278-286.
  52. Desai MM, Sonone S, Bhasme V. Efficacy of alendronate in the treatment of avascular necrosis of the hip [published online ahead of print June 21, 2005]. Rheumatology (Oxford). 2005; 44(10):1331-1332.
  53. Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg Am. 2005; 87(10):2155-2159.
  54. Zaidi M, Sun L, Robinson LJ, et al. ACTH protects against glucocorticoid-induced osteonecrosis of bone [published online ahead of print April 26, 2010]. Proc Natl Acad Sci U S A. 2010; 107(19):8782-8787.
  55. Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY. Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Joint Surg Am. 2005; 87(11):2380-2387.
  56. Reis ND, Schwartz O, Militianu D, et al. Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head. J Bone Joint Surg Br. 2003; 85(3):371-375.
  57. Kim HJ. Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head. J Bone Joint Surg Br. 2004; 86(1):150-151.
  58. Bozic KJ, Zurakowski D, Thornhill TS. Survivorship analysis of hips treated with core decompression for nontraumatic osteonecrosis of the femoral head. J Bone Joint Surg Am. 1999; 81(2):200-209.
  59. Stulberg BN, Davis AW, Bayer TW, Levine M, Easley K. ON of the femoral head. A prospective randomized treatment protocol. Clin Orthop Relat Res. 1991; (268):140-151.
  60. Aaron RK, Ciombor DM, Lord CF. Core decompression augmented with human decalcified bone matrix graft for osteonecrosis of the femoral head. In: Urbaniak JR, Jones JP, editors. Osteonecrosis: Etiology, Diagnosis, and Treatment. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1997:301-307.
  61. Iwata H, Torii S, Hasegawa Y, et al. Indications and results of vascularized pedicle iliac bone graft in avascular necrosis of the femoral head. Clin Orthop Relat Res. 1993; (295):281-288.
  62. Urbaniak JR, Coogan PG, Gunneson EB, Nunley JA. Treatment of osteonecrosis of the femoral head with free vascularized fibular grafting. A long-term follow-up study of one hundred and three hips. J Bone Joint Surg Am. 1995; 77(5):681-694.
  63. Steinberg ME, Larcom PG, Stafford BB, et al. Treatment of osteonecrosis of the femoral head by core decompression, bone grafting, and electrical stimulation. In: Urbaniak JR, Jones JP, editors. Osteonecrosis: Etiology, Diagnosis, and Treatment. Rosemont; IL: American Academy of Orthopaedic Surgeons; 1997:293-299.
  64. Aaron RK, Lennox D, Bunce GE, Ebert T. The conservative treatment of osteonecrosis of femoral head. A comparison of core decompression and pulsing electromagnetic fields. Clin Orthop Relat Res. 1989; (249):209-218.
  65. Cui Q, Xiao Z, Li X, Saleh KJ, Balian G. Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study. J Bone Joint Surg Am. 2006; 88(supplement 3):167-172.
  66. Lieberman JR, Conduah A, Urist MR. Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein. Clin Orthop Relat Res. 2004; (429):139-145.
  67. Hernigou P, Poignard A, Manicom O, Mathieu G, Rouard H. The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone. J Bone Joint Surg Br. 2005; 87(7):896-902.
  68. Gangji V, Toungouz M, Hauzeur JP. Stem cell therapy for osteonecrosis of the femoral head. Expert Opin Biol Ther. 2005; 5(4):437-442.
  69. Hernigou P, Beaujean F. Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res. 2002; (405):14-23.
  70. Ko JY, Meyers MH, Wenger DR. “Trapdoor” procedure for osteonecrosis with segmental collapse of the femoral head in teenagers. J Pediatr Orthop. 1995; 15(1):7-15.
  71. Mont MA, Einhorn TA, Sponseller PD, Hungerford DS. The trapdoor procedure using autogenous cortical and cancellous bone grafts for osteonecrosis of the femoral head. J Bone Joint Surg Br. 1998; 80(1):56-62.
  72. Sotereanos DG, Plakseychuk AY, Rubash HE. Free vascularized fibula grafting for the treatment of osteonecrosis of the femoral head. Clin Orthop Relat Res. 1997; (344):243-256.
  73. Beris AE, Soucacos PN. Optimizing free fibular grafting in femoral head osteonecrosis: the Ioannina aiming device. Clin Orthop Relat Res. 2001; (386):64-70.
  74. Urbaniak JR, Harvey EJ. Revascularization of the femoral head in osteonecrosis. J Am Acad Orthop Surg. 1998; 6(1):44-54.
  75. Rosenwasser MP, Garino JP, Kiernan HA, Michelsen CB. Long term followup of thorough debridement and cancellous bone grafting of the femoral head for avascular necrosis. Clin Orthop Relat Res. 1994; (306):17-27.
  76. Boettcher WG, Bonfiglio M, Smith K. Non-traumatic necrosis of the femoral head. II. Experiences in treatment. J Bone Joint Surg Am. 1970; 52(2):322-329.
  77. Smith KR, Bonfiglio M, Montgomery WJ. Non-traumatic necrosis of the femoral head treated with tibial bone-grafting. A follow-up note. J Bone Joint Surg Am. 1980; 62(5):845-847.
  78. Dunn AW, Grow T. Aseptic necrosis of the femoral head. Treatment with bone grafts of doubtful value. Clin Orthop Relat Res. 1977; (122):249-254.
  79. Buckley PD, Gearen PF, Petty RW. Structural bone-grafting for early atraumatic avascular necrosis of the femoral head. J Bone Joint Surg Am. 1991; 73(9):1357-1364.
  80. Sugioka Y, Hotokebuchi T, Tsutsui H. Transtrochanteric anterior rotational osteotomy for idiopathic and steroid-induced necrosis of the femoral head-indications and long-term results. Clin Orthop Relat Res. 1992; (277):111-120.
  81. Inao S, Ando M, Gotoh E, Matsuno T. Minimum 10 year results of Sugioka’s osteotomy for femoral head osteonecrosis. Clin Orthop Relat Res. 1999; (368):141-148.
  82. Fuchs B, Knothe U, Hertel R, Ganz R. Femoral osteotomy and iliac graft vascularization for femoral head osteonecrosis. Clin Orthop Relat Res. 2003; (412):84-93.
  83. Nakamura Y, Kumazawa Y, Mitsui H, Toh S, Katano H. Combined rotational osteotomy and vascularized iliac bone graft for advanced osteonecrosis of the femoral head. J Reconstr Microsurg. 2005; 21(2):101-105.
  84. Canadell J, Aguilella L, Azcarate JR, Valenti JR. The place of intertrochanteric osteotomy in the treatment of idiopathic necrosis of the head of the femur. Int Orthop. 1986; 10(1):41-46.
  85. Veillette CJH, Mehdian H, Schemitsch EH, McKee MD. Survivorship analysis and radiographic outcome following tantalum rod insertion for osteonecrosis of the femoral head. J Bone Joint Surg Am. 2006; 88(supplement 3):48-55.
  86. Tanzer M, Karabasz D, Krygier JJ, Cohen R, Bobyn JD. The Otto Aufranc Award: bone augmentation around and within porous implants by local bisphosphonate elution. Clin Orthop Relat Res. 2005; (441):30-39.
  87. Tsao AK, Roberson JR, Christie MJ, et al. Biomechanical and clinical evaluations of a porous tantalum implant for the treatment of early-stage osteonecrosis. J Bone Joint Surg Am. 2005; 87(suppl 2):22-27.
  88. Tanzer M, Bobyn JD, Krygier JJ, Karabasz D. Histopathologic retrieval analysis of clinically failed porous tantalum osteonecrosis implants. J Bone Joint Surg Am. 2008; 90(6):1282-1289.
  89. Chiu KH, Shen WY, Ko CK, Chan KM. Osteonecrosis of the femoral head treated with cementless total hip arthroplasty. A comparison with other diagnoses. J Arthroplasty. 1997; 12(6): 683-688.
  90. Stulberg BN, Singer R, Goldner J, Stulberg J. Uncemented total hip arthroplasty in osteonecrosis: a 2- to 10-year evaluation. Clin Orthop Relat Res. 1997; (334):116-123.
  91. Archibeck MJ, Jacobs JJ, Black J. Alternate bearing surfaces in total joint arthroplasty: biologic considerations. Clin Orthop Relat Res. 2000; (379):12-21.
  92. Beaulé PE, Amstutz HC. Management of Ficat stage III and IV osteonecrosis of the hip. J Am Acad Orthop Surg. 2004; 12(2):96-105.
  93. Cuckler JM, Moore KD, Estrada L. Outcome of hemiresurfacing in osteonecrosis of the femoral head. Clin Orthop Relat Res. 2004; (429):146-150.
  94. Grecula MJ, Thomas JA, Kreuzer SW. Impact of implant design on femoral head hemiresurfacing arthroplasty. Clin Orthop Relat Res. 2004; (418):41-47.
  95. Adili A, Trousdale RT. Femoral head resurfacing for the treatment of osteonecrosis in the young patient. Clin Orthop Relat Res. 2003; (417):93-101.
  96. Chan YS, Shih CH. Bipolar versus total hip arthroplasty for hip osteonecrosis in the same patient. Clin Orthop Relat Res. 2000; (379):169-177.
  97. Ito H, Matsuno T, Kaneda K. Bipolar hemiarthroplasty for osteonecrosis of the femoral head. A 7- to 18-year followup. Clin Orthop Relat Res. 2000; 374:201-211.
  98. Sanjay BK, Moreau PG. Bipolar hip replacement in sickle cell disease. Int Orthop. 1996; 20(4):222-226.
  99. Takaoka K, Nishina T, Ohzono K, et al. Bipolar prosthetic replacement for the treatment of avascular necrosis of the femoral head. Clin Orthop Relat Res. 1992; (277):121-127.
  100. Mont MA, Ragland PS, Etienne G. Core decompression of the femoral head for osteonecrosis using percutaneous multiple small-diameter drilling. Clin Orthop Relat Res. 2004; (429):131-138.
  101. Beaulé PE, Schmalzried TP, Campbell P, Dorey F, Amstutz HC. Duration of symptoms and outcome of hemiresurfacing for hip osteonecrosis. Clin Orthop Relat Res. 2001; (385):104-117.

Drs Babis, Sakellariou, and Soucacos are from 1st Orthopaedic Department, University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece; and Dr Parvizi is from the Rothman Institute of Orthopaedics at Thomas Jefferson University, Philadelphia, Pennsylvania.

The material presented in any Vindico Medical Education continuing education activity does not necessarily reflect the views and opinions of ORTHOPEDICS or Vindico Medical Education. Neither ORTHOPEDICS nor Vindico Medical Education nor the authors endorse or recommend any techniques, commercial products, or manufacturers. The authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or using any product.

Correspondence should be addressed to: George C. Babis, MD, PhD, 1st Orthopaedic Department, University of Athens, Attikon University General Hospital, 1 Rimini Str, Chaidari, Greece, 12462 (george.babis@gmail.com, b_sakellariou@yahoo.com).

doi: 10.3928/01477447-20101123-19

10.3928/01477447-20101123-19

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