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Patients with tibial plafond fractures had greater inflammatory response vs rotational ankle fractures

Lucas S. Marchand

LAS VEGAS — Compared with rotational ankle fractures, patients with tibial plafond fractures showed significant elevation of several cytokines, according to results presented at the American Academy of Orthopaedic Surgeons Annual Meeting

Lucas S. Marchand, MD, and colleagues performed synovial fluid aspiration at the time of presentation or at index surgery for 26 patients with rotational ankle fractures and 23 patients with tibial plafond fractures to measure the inflammatory response. Marchand noted they quantified interleukin-1 beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10 and tumor necrosis factor-alpha concentrations.

Despite no significant differences in demographic data or injury severity scores between the two groups, Marchand noted patients with tibial plafond fractures had significantly elevated levels of IL-10, IL-1 beta, IL-6 and IL-8.

“The levels of IL-1 [receptor antagonist] RA and TNF-alpha remained the same between the two groups or at least did not reach statistical significance,” Marchand said.

To compare the different types of rotational ankle fractures, including bimalleolar fractures, bimalleolar fractures with a syndesmotic injury and trimalleolar dislocations, researchers performed a subgroup analysis.

“We see here that the cytokine levels did differ in the bimalleolar and syndesmotic and trimalleolar ankle fractures if you compare them to the isolated bimalleolar injuries but again, we didn’t quite reach statistical significance,” Marchand said. – by Casey Tingle

 

Reference:

Marchand LS, et al. Abstract 291. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 12-15, 2019; Las Vegas.

 

Disclosure: Marchand reports no relevant financial disclosures.

Lucas S. Marchand

LAS VEGAS — Compared with rotational ankle fractures, patients with tibial plafond fractures showed significant elevation of several cytokines, according to results presented at the American Academy of Orthopaedic Surgeons Annual Meeting

Lucas S. Marchand, MD, and colleagues performed synovial fluid aspiration at the time of presentation or at index surgery for 26 patients with rotational ankle fractures and 23 patients with tibial plafond fractures to measure the inflammatory response. Marchand noted they quantified interleukin-1 beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10 and tumor necrosis factor-alpha concentrations.

Despite no significant differences in demographic data or injury severity scores between the two groups, Marchand noted patients with tibial plafond fractures had significantly elevated levels of IL-10, IL-1 beta, IL-6 and IL-8.

“The levels of IL-1 [receptor antagonist] RA and TNF-alpha remained the same between the two groups or at least did not reach statistical significance,” Marchand said.

To compare the different types of rotational ankle fractures, including bimalleolar fractures, bimalleolar fractures with a syndesmotic injury and trimalleolar dislocations, researchers performed a subgroup analysis.

“We see here that the cytokine levels did differ in the bimalleolar and syndesmotic and trimalleolar ankle fractures if you compare them to the isolated bimalleolar injuries but again, we didn’t quite reach statistical significance,” Marchand said. – by Casey Tingle

 

Reference:

Marchand LS, et al. Abstract 291. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 12-15, 2019; Las Vegas.

 

Disclosure: Marchand reports no relevant financial disclosures.

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