This activity is brought to you by Flexion Therapeutics, Inc.
During the American Academy of Orthopaedic Surgeons 2019 annual meeting, Andrew I. Spitzer, MD, gave a presentation, sponsored by Flexion Therapeutics, Inc., about the management of osteoarthritis (OA). This education lab activity summarizes the key discussion points from the presentation, including review of the disease state, treatment options for patients with knee-related OA, and safety and efficacy of intra-articular corticosteroid treatments.
Disease state of osteoarthritis
Osteoarthritis (OA), the most common form of arthritis, affects >30 million adults in the United States, including one-fifth of those over the age of 45 years.1-3 Given that OA is the most frequent cause of disability in adults, the health-related burden is significant with an estimated total cost to the US economy of $100 billion and lost earnings of $80 billion.1,4,5
OA is progressively recognized as a serious disease with an associated increased risk of comorbidity such as obesity (60%), cardiovascular disease (40%), and diabetes (up to 30%). Furthermore, patients with OA have excess all-cause mortality compared with the general population, and history of diabetes, cancer, cardiovascular disease or walking disability constitute major risk factors. An additional possible explanation for the excess mortality beyond these comorbid risk factors include reduced physical activity and/or a sedentary lifestyle.5-9
The most frequent site of involvement is the knee, with lifetime risk estimates of 45% for adults in the United States.1,10 Injury or overuse of joints increases susceptibility. The prevalence of symptomatic knee OA has increased in recent decades in direct correlation with the aging of the population and increased levels of obesity, and has nearly doubled since the mid-twentieth century. In the United States, 14 million individuals are now affected.1,11,12
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