Platelet-rich plasma had a positive effect on tenocyte proliferation and recovery on initial application, according to study results. However, the effect was diminished with repetitive application.
Researchers collected venous blood from eight participants from new blood draws at three different times. On each day of treatment, the researchers prepared platelet-rich plasma derived from a single-spin process (PRPSS) and from a double-spin process (PRPDS). Tenocytes were exposed to three separate treatments of PRPSS, PRPDS and media at either 0, 2 and 4 days or 0, 4 and 8 days. The researchers then examined cell proliferation, measured as disintegrations per minute via a radioactive thymidine assay.
Results showed statistical significance in the difference in disintegrations per minute between days 0 and 2 in the PRPSS 2-day-interval group. Statistical difference was also seen in the PRPDS group between days zero and 4 and between days 2 and 4.
The researchers found a decrease in cell proliferation in the PRPSS 4-day interval group, with the difference in disintegrations per minute between days 4 and 8 reaching statistical significance. The PRPDS group also showed a decrease in cell proliferation with a statistical difference between days 0 and 8, according to the researchers. – by Casey Tingle
Disclosure: Mazzocca is a paid consultant for Arthrex. Please see the full study for a list of all other authors’ relevant financial disclosures.