Autologous bone marrow-derived mesenchymal stem cells may play a role in the formation of new bone in non-union fracture sites, according to this study.
Researchers from the Robert Jones and Agnes Hunt Orthopaedic Hospital and Keele University in United Kingdom conducted a double-blinded study of 35 patients (21 men and 14 women). The patients acted as their own control, with one side of the fracture site receiving serum while the other was inserted with bone marrow-derived mesenchymal stem cells (BMMSC), according to the abstract.
“In summary, cells from non-union site show reduced capacity for bone regeneration and hence augmenting them with autologous BMMSC can possibly stimulate new bone formation in a setting of non-union,” the researchers stated in the abstract.
Six reviewers independently analyzed the radiographics, and interim results showed improvement on side that received autologous BMMSC compared to the side of the fracture that received serum alone, according to the abstract.