Researchers of this study found good results in patients with focal lesions of the condylar articular cartilage treated with arthroscopic microfracture and autologous bone marrow concentrate covered with either a collagen membrane or a polyglycolic acid/hyaluronan scaffold.
"The first clinical experience with single-stage covered microfracture and bone marrow concentrate (CMBMC) for focal cartilage defects in the knee suggests that it is safe, it improves the short-term knee function and that it has the potential to recreate hyaline-like cartilage,” the researchers stated in the abstract. “No significant difference was observed between [collagen] C-covered or [polyglycolic acid/hyaluronan] PH-covered CMBMC.
All 18 patients showed significantly improved International Knee Documentation Committee subjective score, Lysholm score, VAS score and median Tegner score at average 26-month follow-up, according to the abstract. Researchers noted no significant difference between the groups.
A macroscopic cartilage assessment at 12 months revealed one normal repair, one abnormal repair and seven nearly normal repairs, according to the abstract. The researchers also conducted a histological analysis and found a fibrocartilaginous repair in three lesions, a hyaline-like cartilage repair in two lesions and a mixture of both fibrocartilaginous and hyaline-like repairs in one lesion.