Compared with high tibial osteotomy with platelet-rich plasma injection only, patients who underwent high tibial osteotomy in conjunction with mesenchymal stem cell therapy and platelet-rich plasma injection had mildly improved cartilage healing and good clinical results, according to study results.
Researchers divided patients to receive high tibial osteotomy (HTO) with platelet-rich plasma (PRP) injection only or HTO in conjunction with mesenchymal stem cell (MSC) therapy and PRP injection. Using the Lysholm score, KOOS and VAS pain score, the researchers performed prospective evaluations for both groups. All patients underwent second-look arthroscopy at the time of metal removal.
Results showed greater improvements in the KOOS subscales for pain and symptoms among patients in the MSC-PRP group. The researchers also found the mean Lysholm score was similarly improved in both groups. However, significantly greater improvement in the VAS pain score was found in the MSC-PRP group.
No differences were found in the preoperative and postoperative femorotibial angles or weight-bearing lines between the groups, according to the researchers.
At plate removal, arthroscopic evaluation showed only 10% of the patients in the PRP-only group achieved partial or even fibrocartilage coverage vs. 50% of patients in the MSC-PRP group.
Disclosure: The authors have no relevant financial disclosures.