According to recently published results, NSAID use may contribute to the link between osteoarthritis and cardiovascular disease.
“NSAIDs are some of the most commonly used drugs to manage pain, so it’s important for people with osteoarthritis to have a conversation with their care providers about the risk of these medicines potentially outweighing the benefits,” study co-author Aslam H. Anis, PhD, FCAHS, told Healio.com/Orthopedics.
Researchers identified 7,743 patients with OA and 23,229 non-OA controls. The risk of developing incident cardiovascular disease, ischemic heart disease, congestive heart failure and stroke was estimated with multivariable Cox proportional hazards models. A marginal structural model was used to estimate the mediating effect of NSAIDs.
Results showed a greater risk of cardiovascular disease in patients with OA compared with patients without OA. The adjusted hazard ratio was 1.23 after investigators adjusted socioeconomic status, BMI, hypertension, diabetes, hyperlipidemia, chronic obstructive pulmonary disease and Romano and comorbidity scores.
Investigators noted the adjusted HRs were 1.42 for congestive heart failure, 1.17 for ischemic heart disease and 1.14 for stroke. Around 41% of the total impact of OA on the increased risk of cardiovascular disease was mediated through NSAIDs. The proportion mediated through NSAIDs was 23% for congestive heart failure, 56% for ischemic heart disease and 64% for stroke. – by Monica Jaramillo
Disclosures: The authors report no relevant financial disclosures.