Researchers postulated that similar risk factors may affect the progression of retinopathy and chronic kidney disease after finding an association between the two.
Prior to this study, there was no known association between the progression of retinopathy and concurrent progression of chronic kidney disease (CKD), the authors said.
Researchers evaluated the data of 1,025 patients with CKD who were enrolled in the multicenter, prospective Chronic Renal Insufficiency Cohort Study. They included patients who underwent two fundus photography sessions, 3.5 years apart, which were reviewed by masked graders for both presence and severity of retinopathy as well as vessel calibers.
The association between the progression of retinopathy and CKD was evaluated using univariable and multivariable logistic regression models.
In the univariable analysis of participants with baseline and follow-up photography, the odds ratio for retinopathy progression associated with CKD progression was 2.24 (95% CI, 1.28-3.91; P = .005). The multivariable analysis revealed an odds ratio of 1.62 (95% CI, 0.77-3.39; P = .20).
Additionally, researchers found a statistically significant association between the progression of retinopathy and CKD in patients without diabetes (odds ratio, 3.42; P = .02).
The authors stated that the pathologic changes in diabetes could possibly affect the progression of CKD.
They concluded that because the link between CKD and retinopathy is not statistically significant after adjustment for known risk factors, the progression of both diseases may be facilitated by similar mechanisms.
Additionally, because a substantial prevalence and progression of retinopathy was found in patients with CKD, those with kidney disease should be monitored for eye disease, they said. – by Scott Buzby
Disclosure: The authors report no relevant financial disclosures.