Macular holes may be attributed to discrete anatomic changes such as thinning of the central fovea, according to a study.
The retrospective, cross-sectional study included 849 eyes: 301 eyes with macular hole, 199 with epiretinal membrane (ERM), 152 with retinal vein occlusion (RVO) and 197 healthy eyes.
Cirrus spectral-domain optical coherence tomography (Carl Zeiss Meditec) was used to obtain axial images of the vitreoretinal interface, retinal thickness and foveal thickness.
Foveal thickness was 243 µm and central foveal thickness was 192 µm in eyes with macular hole; both values were significantly lower than those reported for the ERM, RVO and healthy eye groups (P < .0001).
Differences between foveal and central foveal thickness were insignificant in eyes with ERM, those with RVO and healthy eyes.
Thinner fovea and deeper foveal depression correlated significantly with macular hole (P < .0001).
Disclosures: Masanori Hangai, MD, is a paid advisory board member for NIDEK and received consulting fees from Topcon, lecture fees from Heidelberg Engineering and Santen, and research funding from Nidek, Topcon and Canon. The remaining authors have no relevant financial disclosures.