Full-thickness macular holes were closed successfully in patients with choroideremia, according to a study.
Investigators retrospectively evaluated 30 patients with advanced choroideremia. Full-thickness macular holes (FTMH) were identified in three patients who underwent 23-gauge pars plana vitrectomy with inner limiting membrane peeling and gas tamponade.
In two patients, gas tamponade lasted about 16 weeks, about twice the typical length of time after standard FTMH surgery with 16% octafluoropropane (C3F8). The third patient underwent FTMH surgery with sulfur hexafluoride (SF6), which lasted about 6 weeks. The authors recommended FTMH closure with shorter duration SF6 gas tamponade in patients with choroideremia.
Optical coherence tomography confirmed anatomic closure of macular holes in all cases. Subjective visual acuity improved in all cases but objective metrics showed no improvement.
Anatomic FTMH closure may enable choroideremia patients to undergo sub-retinal gene therapy, the authors said.
“An open macular hole would lead to reflux of vector suspension into the vitreous, leading to a significant reduction in the therapeutic dose given to the [retinal pigment epithelium] and photoreceptors,” they said.
Disclosure: The study authors report no relevant financial disclosures.