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Vitrectomy yields more macular hole closures than Jetrea

BOSTON — Visual outcomes were similar in eyes with bilateral macular holes that underwent a vitrectomy or intravitreal ocriplasmin injection, but primary macular hole closure rates were higher in eyes that underwent a vitrectomy, according to a poster presented here at the American Society of Retina Specialists meeting.

Verena R. Juncal, MD, and colleagues presented the findings of the Canadian study, a multicenter retrospective case series that included 22 eyes of 11 patients with bilateral macular holes. Patients underwent vitrectomy and internal limiting membrane peeling in one eye and 125 μg/0.10 mL Jetrea (ocriplasmin, ThromboGenics) injected in the fellow eye.

Vitrectomy eyes had a statistically significant higher primary macular hole closure rate of 90.9% compared with 36.4% closure rate in ocriplasmin eyes (P = .031). However, the final best corrected visual acuity compared to baseline, which was the primary endpoint, was similar in both groups of eyes, according to the poster.

Vitrectomy eyes had more common transient and persistent OCT outer band changes when compared with ocriplasmin eyes. – by Robert Linnehan

Reference:

Juncal VR, et al. Ocriplasmin versus vitrectomy for the treatment of macular holes. Presented at: American Society of Retina Specialists 35th Annual Meeting, Aug. 11-15, 2017; Boston.

Disclosure: Juncal reports no relevant financial disclosures.

BOSTON — Visual outcomes were similar in eyes with bilateral macular holes that underwent a vitrectomy or intravitreal ocriplasmin injection, but primary macular hole closure rates were higher in eyes that underwent a vitrectomy, according to a poster presented here at the American Society of Retina Specialists meeting.

Verena R. Juncal, MD, and colleagues presented the findings of the Canadian study, a multicenter retrospective case series that included 22 eyes of 11 patients with bilateral macular holes. Patients underwent vitrectomy and internal limiting membrane peeling in one eye and 125 μg/0.10 mL Jetrea (ocriplasmin, ThromboGenics) injected in the fellow eye.

Vitrectomy eyes had a statistically significant higher primary macular hole closure rate of 90.9% compared with 36.4% closure rate in ocriplasmin eyes (P = .031). However, the final best corrected visual acuity compared to baseline, which was the primary endpoint, was similar in both groups of eyes, according to the poster.

Vitrectomy eyes had more common transient and persistent OCT outer band changes when compared with ocriplasmin eyes. – by Robert Linnehan

Reference:

Juncal VR, et al. Ocriplasmin versus vitrectomy for the treatment of macular holes. Presented at: American Society of Retina Specialists 35th Annual Meeting, Aug. 11-15, 2017; Boston.

Disclosure: Juncal reports no relevant financial disclosures.

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