Journal of Refractive Surgery

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Original Article 

Comparison of Corneal Deposits After LASIK and PRK in Eyes With Granular Corneal Dystrophy Type II

Tae-im Kim, MD; Terry Kim, MD; Sun Woong Kim, MD; Eung Kweon Kim, MD, PhD

Abstract

PURPOSE

To compare the characteristics of corneal deposits in eyes with granular corneal dystrophy type II (Avellino corneal dystrophy) after LASIK and photorefractive keratectomy (PRK).

METHODS

Patients with heterozygous granular corneal dystrophy type II were examined with slit-lamp microscopy for recurrence of granular corneal dystrophy type II after uneventful LASIK and PRK surgery. One particular case involved bilateral incomplete flaps after LASIK, resulting in excimer laser ablation under the flap in one area and surface ablation in another area of both eyes. Deoxyribonucleic acid sequencing analysis in all patients confirmed the heterozygous status of granular corneal dystrophy type II.

RESULTS

An abundance of coarse, white opacities consistent with granular corneal dystrophy type II were observed along the interface in all of the LASIK cases. In comparison, only a mild increase in opacities was noted in the PRK cases. In the LASIK case with bilateral incomplete flaps, abundant opacities were present in both corneas along the interface of the LASIK flap, and a minimal increase of stromal opacities was noted where no LASIK flap was present.

CONCLUSIONS

Exacerbation of granular corneal dystrophy type II deposits occurred in the corneal stroma to a much greater degree after LASIK compared to surface ablation surgery. [J Refract Surg. 2008;24:392-395.]

ABOUT THE AUTHORS

From Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (T-I. Kim, S.W. Kim, E.W. Kim); BK21 Project Team of Nanobiomaterials for Cell-based Implants, Yonsei University, Seoul, Korea (T-I. Kim, S.W. Kim, E.W. Kim); and Duke University Eye Center, Durham, NC (T. Kim).

This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050554).

The authors have no proprietary interest in the materials presented herein.

Correspondence: Eung Kweon Kim, MD, PhD, Dept of Ophthalmology, Yonsei University College of Medicine, Seodaemungu Shinchondong 134, CPO Box 8044, Seoul, Korea; Tel: 822 2228 3570; Fax: 822 312 0541; E-mail: eungkkim@yumc.yonsei.ac.kr

Received: January 8, 2007

Accepted: March 12, 2007

Posted online: July 16, 2007

Abstract

PURPOSE

To compare the characteristics of corneal deposits in eyes with granular corneal dystrophy type II (Avellino corneal dystrophy) after LASIK and photorefractive keratectomy (PRK).

METHODS

Patients with heterozygous granular corneal dystrophy type II were examined with slit-lamp microscopy for recurrence of granular corneal dystrophy type II after uneventful LASIK and PRK surgery. One particular case involved bilateral incomplete flaps after LASIK, resulting in excimer laser ablation under the flap in one area and surface ablation in another area of both eyes. Deoxyribonucleic acid sequencing analysis in all patients confirmed the heterozygous status of granular corneal dystrophy type II.

RESULTS

An abundance of coarse, white opacities consistent with granular corneal dystrophy type II were observed along the interface in all of the LASIK cases. In comparison, only a mild increase in opacities was noted in the PRK cases. In the LASIK case with bilateral incomplete flaps, abundant opacities were present in both corneas along the interface of the LASIK flap, and a minimal increase of stromal opacities was noted where no LASIK flap was present.

CONCLUSIONS

Exacerbation of granular corneal dystrophy type II deposits occurred in the corneal stroma to a much greater degree after LASIK compared to surface ablation surgery. [J Refract Surg. 2008;24:392-395.]

ABOUT THE AUTHORS

From Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (T-I. Kim, S.W. Kim, E.W. Kim); BK21 Project Team of Nanobiomaterials for Cell-based Implants, Yonsei University, Seoul, Korea (T-I. Kim, S.W. Kim, E.W. Kim); and Duke University Eye Center, Durham, NC (T. Kim).

This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050554).

The authors have no proprietary interest in the materials presented herein.

Correspondence: Eung Kweon Kim, MD, PhD, Dept of Ophthalmology, Yonsei University College of Medicine, Seodaemungu Shinchondong 134, CPO Box 8044, Seoul, Korea; Tel: 822 2228 3570; Fax: 822 312 0541; E-mail: eungkkim@yumc.yonsei.ac.kr

Received: January 8, 2007

Accepted: March 12, 2007

Posted online: July 16, 2007

10.3928/1081597X-20080401-13

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